Project Grant K99GM160778
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- The National Institute of General Medical Sciences (NIGMS) awarded a $501,917 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant supports research dedicated to elucidating the molecular mechanisms of RNA-guided biological systems, with a focus on CRISPR-associated transposons (CATs) and emerging RNA-guided gene regulation functions. The research aims to dissect the complex interactions and structural dynamics of these natural...
- This federal Project Grant award, with a total funding of $522,764, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant aims to develop a platform technology based on the PiggyBac (PB) transposase, which facilitates precise DNA insertion into specific genomic sequences with minimal off-target effects. This novel gene integration approach is intended to address the limitations of current...
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- The University of Pennsylvania was awarded a $443,806 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research investigating the collective impacts and regulatory mechanisms of multiple enzyme-mediated modifications across distinct RNA species, particularly in the areas of mRNA, tRNA, and rRNA. The research aims to uncover the extent of crosstalk in...
- This federal Project Grant award, valued at $365,625.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the mechanisms by which TET family enzymes act on 5-methylcytosine in genomic DNA and to exploit these insights to devise controllable epigenome editors. The research, conducted by The Trustees of the University of Pennsylvania, will focus on understanding cytosine...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This $138,459 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to uncover the function and protein subcellular localization of bicistronic loci in the green alga Auxenochlorella protothecoides. The research aims to use gene replacement methods to create mutant strains and compare them to wild-type for phenotyping, including physiological and biochemical...
- This Project Grant award of $429,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the biogenesis and function of cyclic phosphate-containing small non-coding RNAs (CP-RNAs). The award, effective February 8, 2025 through December 31, 2029, will enable a genome-wide expression analysis of short CP-RNAs across various cells and tissues. Key objectives include: 1) determining that...
This federal Project Grant award of $119,907 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to dissect the dynamics, functions, and evolution of TNPB, a miniature RNA-guided enzyme. The research aims to enhance the genome-editing efficiency of TNPB and expand its applications beyond DNA cleavage. Specifically, the project seeks to address three key knowledge gaps: (1) the molecular determinants of TNPB's editing efficiency, (2) the co-evolution between TNPB and its guide RNA, and (3) the maturation pathway of the guide RNA. The award was granted to the University of California, Berkeley, a leading research institution, and the project will run from August 1, 2025, to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $119.9k | 7/28/25 |