This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $484,625 in funding to The Washington University in St. Louis to conduct research on the spatiotemporal regulation of organelle interactions and metabolism. The 5-year project, running from May 1, 2025 to March 31, 2030, aims to biophysically and structurally define how lipolytic complexes are assembled and regulated by...
The federal Project Grant award R35GM156863 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to investigate the mechanisms and functions of lipid recycling for cellular metabolism. The $422,500 award, spanning January 1, 2025 to November 30, 2029, will enable researchers at President and Fellows of Harvard College to: Elucidate the regulatory mechanisms underlying the autophagic lipid...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,130,886 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the multimodal regulation of intracellular lipid surveillance. The 4-year project aims to elucidate the molecular mechanisms by which cells sense and respond to changes in lipid homeostasis, with a focus on understanding...
This $307,015 federal Project Grant awarded by the National Science Foundation's Biological Sciences program to the University of Utah aims to investigate the mechanisms regulating the lipid droplet proteome. The research will use multiscale simulations and collaborative experiments to understand how proteins selectively target and interact with lipid droplets in response to varying metabolic conditions. Findings from this work could provide insights to guide future therapeutic interventions for...
This federal Project Grant award of $538,357.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to define the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis. The research seeks to leverage innovative methods, including in vivo studies, multi-omics analyses, and high-resolution imaging mass...
This $355,111 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the Pennington Biomedical Research Center to better understand the mechanisms and role of glycophagy, a process of glycogen degradation within lysosomes, and its contribution to cellular metabolism. The award will fund the development of novel genetically modified cells and mice, as well as innovative tools, to...
This $778,444 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the structure and function of phospholipids and inositol phosphates in the cell nucleus. The 5-year project at Vanderbilt University Medical Center, beginning May 2025, aims to reveal the structural biology and functional genomics of these nuclear signaling molecules. Key objectives include...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) is focused on unraveling the molecular connections between circadian rhythms and lipid metabolism. The $574,021 award, made on February 1, 2025, will support research at the University of Missouri System to address three key knowledge gaps: 1) how the lipid molecule phosphatidic acid (PA) mediates nuclear processes, 2) how PA and lipid...
This federal Project Grant award, valued at $700,000.00 and provided by the National Institute of General Medical Sciences (NIGMS) through the Biomedical Research and Research Training Program (CFDA 93.859), will support research conducted by the Pennington Biomedical Research Center to investigate the role of adipocyte cytokine signaling in regulating adipose tissue function and inflammation. Specifically, the research aims to test the hypotheses that continued exposure of adipocytes to the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...