This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,400,000.00 in funding to the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The overarching goal of the research is to investigate the role of adipocyte cytokine signaling in regulating adipose tissue function, inflammation, and insulin sensitivity. Specifically, the study aims to test the hypotheses that...
This $484,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the spatiotemporal regulation of organelle interactions and metabolism. The award will allow The Washington University to biophysically and structurally define how lipid droplet lipolytic complexes are assembled and regulated by protein networks, employ optical biosensors to examine how organelle...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $539,220 project grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The grant's objective is to study the contribution of rapid nutrient delivery to gut-brain axis signaling in obesity and bariatric surgery. The research aims to: 1) Establish rapid intestinal nutrient delivery as a driver of the gut...
This federal Project Grant award, valued at $450,000.00 and awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the roles of the lysine acetyltransferase KAT8 in adipocyte function and its impact on lipoatrophy and systemic insulin resistance. The long-term objective is to understand how adipocyte KAT8 contributes to adipose tissue function and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide approximately $107,987 to the Pennington Biomedical Research Center in Baton Rouge, Louisiana over a 5-year period from Sep 1, 2024 to Aug 31, 2029. The purpose of this grant is to host an annual 5-day "Clinical Methods for Nutrition and Obesity Research" course...
This $316,368 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the molecular mechanisms underlying metabolic adaptation in human cells. The project aims to quantitatively investigate how the autophagy and cytochrome P450 metabolic pathways respond to nutrient and xenobiotic stresses. By synergizing microscopy, genomics, and proteomics approaches, the research will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $421,600.00 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered include: Elucidating genetic and environmental contributions to human cell fitness, with a focus on three areas: a) understanding context-dependent...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,106,322 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Oregon (UO) on July 15, 2024. This grant supports a 5-year research program to investigate how the host nutrient environment drives bacteria to adopt recalcitrant physiological states, such as slow growth and biofilm formation, that enable chronic infections and antibiotic resistance. The research integrates techniques like...
The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
This $145,642 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at William Marsh Rice University to investigate the role of autophagy inducers and peroxisomal proteins in pexophagy. The research aims to improve understanding of peroxisome regulation, which could have implications for metabolic illnesses in humans and metabolic engineering in crops. The key products or...