Project Grant 2341008
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms of lipid droplet protein targeting. The project aims to determine how proteins are targeted to and removed from lipid droplets in human cells, with a focus on understanding the structural basis and physiological...
- This Project Grant award of $484,625.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting research into the spatiotemporal regulation of organelle interactions and metabolism. The principal investigator at The Washington University aims to gain a mechanistic understanding of lipid metabolism, particularly the role of lipid droplets in metabolic diseases like insulin resistance, obesity, and...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is providing $414,000.00 to Lewis & Clark College from August 1, 2024 to July 31, 2027 to investigate the role of lipid metabolism in the biogenesis of lysosome-related organelles (LROs). The research aims to gain a better understanding of the processes controlling LRO morphology by studying the ACDH-11 protein and its...
- The National Institute of General Medical Sciences (NIGMS) awarded a $609,493 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sloan-Kettering Institute for Cancer Research. The grant, awarded on June 1, 2025 with a final completion date of May 31, 2030, supports fundamental scientific research to unravel the molecular mechanisms underlying lipid and energy storage in eukaryotic cells. Key objectives include: 1) elucidating the structure, function,...
- This $415,311 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), will fund research into the biophysical effects of reversible lipid modification of integral membrane proteins. Using computer modeling and simulations, Syracuse University researchers will study how attaching lipid chains affects the structure and interactions of membrane proteins. Specifically, the project will characterize the...
- This three-year $1.28 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Washington State University to develop a quantitative understanding of lipid metabolic network structure, fluxes, and sub-cellular spatial organization in plant seeds. The goal is to elucidate how plants balance oil accumulation with membrane lipid synthesis to optimize seed oil production without affecting membrane properties. The project will...
- This $639,461 Project Grant awarded by the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at the University of Denver to study the role of the lipid-modifying enzyme phospholipase D (PLD) and its product phosphatidic acid (PA) in the formation and release of cellular communication packets called exosomes. The project, led by Dr. Michelle Knowles, will use advanced microscopy and biochemical techniques to map the spatiotemporal dynamics of...
- The National Science Foundation (NSF) awarded a $1,200,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Washington to conduct research on liquid-liquid phase separation in lipid membranes. The 4-year project aims to: 1) test if asymmetric lipid vesicles phase separate similar to flat membranes; 2) develop new methods to determine lipid ratios in coexisting membrane phases and analyze lipid compositions of vesicles; and 3) use Raman imaging and...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences Federal Grant Program (CFDA 47.074) provides $493,916 to the Massachusetts Institute of Technology (MIT) to investigate how proteins and lipids coordinate the formation and function of membrane-associated condensates. The research aims to improve understanding of how the cell surface is organized, which could enable breakthroughs in biotechnology, disease treatment, and fundamental cell biology. The project...
- This two-year Project Grant from the National Science Foundation (NSF) totaling $589,299 will fund research into the molecular mechanisms of protein association with plastoglobule lipid droplets at Michigan State University. The award falls under the NSF's Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the national scientific enterprise through increased knowledge and understanding of major problems confronting the nation....
CAREER: PROBING SPECIFICITY AND COMPETITION IN THE LIPID DROPLET PROTEOME -LIPID DROPLETS (LD) ARE THE CELLULAR HUBS OF ENERGY STORAGE AND LIPID DISTRIBUTION. AS SUCH THEY PLAY A CENTRAL ROLE IN A WIDE RANGE OF HEALTH ISSUES FROM OBESITY AND DIABETES TO ATHEROSCLEROSIS AND LIVER DISEASES. THIS RESEARCH AIMS TO UNDERSTAND HOW PROTEINS SPECIFICALLY BIND TO LIPID DROPLETS TO CONTROL THEIR LIFECYCLE AND METABOLIC OUTCOMES. MULTISCALE SIMULATIONS AND COORDINATED COLLABORATIVE EXPERIMENTS WILL BE USED TO QUERY THE MECHANISMS BEHIND SELECTIVE TARGETING OF LIPID DROPLETS WITH DIFFERENT NEUTRAL LIPID COMPOSITIONS AND SPECIFIC TARGETING IN RESPONSE TO METABOLIC CONDITIONS, SUCH AS EXCESS ENERGY STORAGE OR STARVATION. WE WILL ALSO PROBE TWO NEW POTENTIAL MECHANISMS OF REGULATION: KINETIC SELECTION AND ALLOSTERIC PROTEIN ASSOCIATION THROUGH ALTERED SURFACE PROPERTIES. THE INTELLECTUAL MERIT OF THIS RESEARCH WILL BE ADVANCING OUR UNDERSTANDING OF LD BIOLOGY, WHILE THE BROADER IMPACTS WILL BE ESTABLISHING A FOUNDATION TO HELP GUIDE FUTURE THERAPEUTIC INTERVENTIONS. ADDITIONALLY, LDS ARE THE PRODUCTION HUBS OF SUSTAINABLE LIPID PRODUCTS FROM MICROBES. THUS, INSIGHTS GAINED IN YEAST AND EUKARYOTIC SYSTEMS WILL BE RELATED TO MICROBIAL SYSTEMS TO AID IN THE DEVELOPMENT OF CLIMATE SOLUTIONS, SUCH AS SCALABLE BIOFUEL AND BIOPLASTIC PRODUCTION. CLOSELY INTEGRATED WITH THESE GOALS, THE EDUCATIONAL PLAN WILL EXPOSE LARGE NUMBERS OF FIRST AND SECOND-YEAR UNDERGRADUATES TO CHEMISTRY, PHYSICS, AND BIOLOGY IN AN ARRAY OF CLIMATE SOLUTIONS, FEATURING AS AN EXAMPLE THE ROLE OF LIPID DROPLETS IN BIOPLASTIC AND BIOENERGY PRODUCTION. LIPID DROPLETS (LDS) ARE NEUTRAL LIPID (NL) STORAGE ORGANELLES THAT PLAY A CENTRAL ROLE IN ENERGY METABOLISM AND LIPID DISTRIBUTION. THEY ARE UNIQUELY SURROUNDED BY PHOSPHOLIPID MONOLAYERS DECORATED WITH A DYNAMIC ARRAY OF PROTEINS. THE PROPOSED RESEARCH AIMS TO PROBE THE MECHANISMS THAT REGULATE THE LD PROTEOME. A SUITE OF MULTISCALE SIMULATION METHODS AND COORDINATED EXPERIMENTAL COLLABORATIONS WILL ADDRESS: 1) HOW PROTEINS SELECTIVELY TARGET CERTAIN POOLS OF LDS BASED ON THEIR NL COMPOSITION; 2) HOW CYTOSOLIC PROTEINS SPECIFICALLY TARGET BASED ON METABOLIC CONDITIONS; AND 3) IF ALLOSTERY AND/OR KINETIC SELECTION INFLUENCE PROTEIN COMPETITION. MULTIPLE METHODOLOGICAL ADVANCES WILL ADDITIONALLY BE DEVELOPED TO ENHANCE OUR ABILITY TO STUDY LDS AND PROTEIN-MONOLAYER INTERACTIONS THROUGH SIMULATIONS. IF SUCCESSFUL, THE PROPOSED RESEARCH WILL ADVANCE OUR UNDERSTANDING OF LD BIOLOGY AND HOW IT INFLUENCES METABOLIC DISORDERS AND DISEASES, SUCH AS OBESITY, DIABETES, LIVER DISEASE, AND ATHEROSCLEROSIS. ADDITIONALLY, LDS ARE THE PRODUCTION HUBS OF SUSTAINABLE LIPID PRODUCTS FROM MICROBES. THUS, THE INSIGHTS GAINED IN YEAST AND EUKARYOTIC SYSTEMS WILL BE RELATED TO MICROBIAL SYSTEMS TO AID THE DEVELOPMENT OF CLIMATE SOLUTIONS, SUCH AS SCALABLE BIOFUEL AND BIOPLASTIC PRODUCTION. CLOSELY INTEGRATED WITH THESE GOALS, THE EDUCATIONAL PLAN WILL EXPOSE LARGE NUMBERS OF FIRST AND SECOND-YEAR UNDERGRADUATES TO CHEMISTRY, PHYSICS, AND BIOLOGY IN AN ARRAY OF CLIMATE SOLUTIONS, FEATURING AS AN EXAMPLE THE ROLE OF LDS IN BIOPLASTIC AND BIOENERGY PRODUCTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $159.8k | 8/27/25 | ||
| Not listed | $307.0k | 12/27/23 |