This $422,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by Harvard University into the mechanisms and functions of cellular lipid recycling. The key products and services to be delivered under this 5-year award include:
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Investigating the regulatory mechanisms underlying the autophagic lipid degradation pathway (lipophagy) and its contribution to cellular lipid metabolism. This builds on the research team's recent discovery of a specific lipophagy receptor.
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Elucidating how lipids are trafficked within cells and utilized at membrane contact sites between organelles to support various cellular functions, including membrane biogenesis, energy production, and signal transduction.
The proposed research aims to reveal fundamental principles of lipid recycling mechanisms that could inform the development of potential therapeutic strategies for metabolic and neurodegenerative disorders involving defective lipid metabolism.
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