This federal Project Grant award for $387,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to understand the roles of microRNAs in animal development. The long-term goal of this research program is to elucidate the gene regulatory mechanisms that enable a single-celled zygote to develop into a multicellular organism. Specifically, the project focuses on studying the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $509,982.00 to the University of Maryland, College Park to conduct research on the fundamental mechanisms governing cell-cell communication that underlie animal development. The primary focus of the research is to unravel the precise regulatory mechanisms controlling the formation and function of signaling filopodia, known...
This federal Project Grant award of $490,841 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanical coordination and mechano-biochemical feedback mechanisms that regulate epithelial tissue folding during embryogenesis. The primary objectives of the research are to: 1) Investigate the feedback regulation of the actomyosin network during apical constriction of cells, 2)...
This Project Grant award of $393,093 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to uncover the relationships between gene expression, cell morphology, and tissue-level mechanics in the context of embryonic development. The goal is to develop an integrative computational framework that can disentangle how genomics, morphology, and mechanics work together to coordinate cellular movement and...
This federal Project Grant award of $413,690.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research into the signals and circuits that regulate developmental timing in the model organism C. elegans. The primary awardee, Northwestern University, will pursue three key goals: (1) delineate the neuronal circuits that accelerate development in response to pheromones, (2) identify signaling pathway components...
This $435,875 five-year Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to enhance the understanding of epithelial cell polarization and behaviors in tissue morphogenesis. The overarching objectives are to investigate the molecular mechanisms of apical intercalation and apical membrane protein sorting in mammary epithelial cells, using in vitro models and in vivo validation...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $104,838 to Duke University to conduct research on understanding how cells interpret and respond to varying inputs from the BMP signaling pathway during embryonic development. The key objectives of the research program are to: 1) Develop a predictive model for BMP target gene transcription that...
This $1,134,576 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at Worcester Polytechnic Institute (WPI) focused on identifying new genes and signaling networks that regulate primary cilia assembly and remodeling in response to environmental stress. The 5-year project will leverage advanced molecular genetics, proteomics, and live cell imaging techniques in C. elegans and...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,675,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Massachusetts Medical School (UMass Medical) to conduct research on the cell biology of mammalian nuclei. The key research focuses on two areas: 1) understanding how the tumor marker protein Ki-67 protects chromosomes, including mapping its chromatin-binding domains and determining the specific genomic loci that are damaged...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $388,750 to the University of Washington to conduct research on the biophysical mechanisms underlying the development of the Drosophila renal system. The goal is to understand how cells coordinate to build the complex 3D architecture of epithelial organ structures, such as looped renal tubules, which is essential for...