Project Grant R35GM158228
- This federal Project Grant award of $277,375.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to examine the sources, fates, and effects of compartmentalized cofactor metabolism in eukaryotic cells. The award to Temple University will allow the researchers to measure the pools of critical cofactors like acyl-CoAs across subcellular compartments and investigate their specific...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $577,280.00 in funding to Northwestern University to conduct research on the "Signaling and Metabolic Regulation of Nucleotide Metabolism and Cell Growth." The award, which began on August 1, 2025 and is slated for completion by May 31, 2030, supports the Principal Investigator's research to uncover fundamental...
- This Project Grant award for $422,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by Harvard University to investigate the mechanisms and functions of lipid recycling for cellular metabolism. The key focus areas are: 1) Elucidating the regulatory mechanisms underlying the autophagic lipid degradation pathway known as lipophagy, which is critical for cellular lipid metabolism, and 2) Examining...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- The Scintillon Institute, a non-profit biomedical research organization, received a $529,650 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of the mitochondrial electron transport chain. The research aims to identify endogenous metabolites interconverted by NQO1 and characterize the bioenergetics of this alternative electron transfer mechanism, with the goal of developing therapeutic...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- This Project Grant award, ID R35GM156443, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $419,375 award, spanning January 1, 2025 to November 30, 2029, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to define the functional dynamics of multidomain redox enzymes, with a focus on nitric oxide synthase (NOS) enzymes. The research aims to gain a comprehensive...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,616 Project Grant to Brown University. The grant, effective from September 1, 2025 to June 30, 2030, will support the development of integrative computational models to decode disease mechanisms and predict drug synergies in spatial transcriptomics. The research aims to uncover how the spatial arrangement of cells within tissues (cellular spatial...
- The federal Project Grant award of $248,967.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Massachusetts aimed at understanding mechanisms that control peroxisomal turnover and how peroxisome dysfunction signals to other cellular organelles. The project, awarded on July 10, 2025, with a completion date of June 30, 2028, will leverage recent findings on the role...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $398,750 to Brown University to investigate the coordinated control of metabolism by enzymes and transporters. The research aims to understand the transport mechanism of nicotinamide (NAM), a precursor for nicotinamide adenine dinucleotide (NAD), which is a critical redox cofactor involved in over 400 biochemical reactions. The project, led by Dr. Karthikeyani Chellappa, will examine how NAM transport and its regulation by the enzyme nicotinamide phosphoribosyl transferase (NAMPT) impact NAD homeostasis, with potential implications for aging, obesity, diabetes, and other diseases. The award period runs from September 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $398.8k | 8/7/25 |