Project Grant R35GM156596
- This $616,401 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on enzyme recruitment and metabolic plasticity. The objective is to use biochemistry, evolution experiments, and -omics methods to investigate how cellular features impact enzyme recruitment, which is a key process enabling the evolution of new metabolic pathways. The research will leverage three...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $421,600 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered under this 5-year award include: Elucidating genetic and environmental contributions to human cell fitness and growth, leveraging innovative tools such as a...
- This federal Project Grant award of $446,875.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress. The primary awardee, The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, will leverage their expertise in...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $398,750 to Brown University to investigate the coordinated control of metabolism by enzymes and transporters. The research aims to understand the transport mechanism of nicotinamide (NAM), a precursor for nicotinamide adenine dinucleotide (NAD), which is a critical redox cofactor involved in over 400 biochemical reactions....
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $416,398 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research on the regulation of neutral lipid metabolism in eukaryotes. The research program at Texas A&M AgriLife Research, a component of the Texas A&M University System, aims to elucidate the underlying mechanisms controlling the enzymatic activity of acyltransferases...
- This Project Grant award of $223,176 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the structure, function, and mechanism of the carbon monoxide dehydrogenase (CODH) enzyme. Specifically, the award will fund the synthesis and spectroscopic study of biomimetic models of the CODH C-cluster, which is responsible for the enzyme's catalytic activity in carbon dioxide reduction and carbon...
This federal Project Grant award of $277,375.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to examine the sources, fates, and effects of compartmentalized cofactor metabolism in eukaryotic cells. The award to Temple University will allow the researchers to measure the pools of critical cofactors like acyl-CoAs across subcellular compartments and investigate their specific functions as signaling molecules and regulators of post-translational protein modifications. Additionally, the project will push the limits of single-cell metabolomics to better understand compartmentalized metabolism. This 5-year research effort, commencing on September 1, 2025, aims to advance the fundamental understanding of eukaryotic metabolism and its implications for human health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $277.4k | 8/19/25 |