The National Institute of General Medical Sciences (NIGMS) awarded a $370,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Texas A&M University in College Station, Texas. The grant, effective from July 1, 2024 to June 30, 2029, aims to leverage single-molecule microscopy techniques to gain a detailed molecular-level understanding of type IV pili (TFP) in the opportunistic pathogen Pseudomonas aeruginosa. Specifically, the research will: 1) Use...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $375,420 from June 1, 2025 to April 30, 2030 to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on the structural and functional mechanisms that enable translation factors to monitor the quality and accuracy of protein synthesis in bacteria. The research aims to elucidate how canonical...
This Project Grant award of $729,010 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize novel phage lysis proteins and their mechanisms of action. The 5-year project, awarded to Texas A&M University, aims to experimentally elucidate the molecular mechanisms of diverse phage lysis proteins, including those found in phages infecting abundant but understudied human gut microbiota....
The University of Washington was awarded a $441,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to conduct research investigating regulators of bacterial chromosome organization. The project aims to: 1) elucidate the mechanism of the GAPR protein as a model for understanding how bacteria and bacteriophages control positive supercoiling to proliferate; 2) identify additional topoisomerase...
This $403,423 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the molecular mechanisms of antibiotic inhibition of ribosomal subunit joining in bacteria. The project aims to characterize the kinetic, thermodynamic, and structural dynamics of the subunit joining process and elucidate how antibiotics impact these parameters. The research comprises three...
This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The research program aims to investigate the molecular mechanisms that control 2',3'-cyclic nucleotide monophosphate (2',3'-cNMP) signaling in bacteria, including its effects on transcription,...
This $1,003,736 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research program has two main sub-projects: 1) Investigating epitranscriptomic regulation of gene expression across various bacterial species, and 2) Exploring the regulatory roles of novel...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,379,734 to the University of Texas at Austin to conduct research on microcin antibacterial proteins. The goal is to better understand how these small proteins can overcome the outer membrane permeability barrier of Gram-negative bacteria, a major challenge in developing new antibiotics. The research aims to link...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,121,773 to the University of Texas at Arlington (UTA) to advance the understanding of how RNA interference (RNAi) pathways are regulated to maintain cellular homeostasis. The research aims to explore mechanisms of target transcript sorting, temporal regulation of RNAi pathways during development, and the molecular and...
This $395,701 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of Texas at Austin to investigate the molecular bases of interactions between bacteria and their hosts. The research aims to (1) understand how bacterial competition and host immune responses shape microbiome composition, (2) examine how hosts selectively allow beneficial bacteria to colonize, and (3)...