Project Grant R35GM158145

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $396K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Texas, USA
Similar Awards
This $854,736 Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports the development of robust statistical methods for analyzing longitudinal microbiome studies. The primary grant recipient, Weill Medical College of Cornell University, will lead the effort to create a comprehensive suite of statistical tools to address key challenges in longitudinal microbiome data analysis,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,379,734 to the University of Texas at Austin to conduct research on microcin antibacterial proteins. The goal is to better understand how these small proteins can overcome the outer membrane permeability barrier of Gram-negative bacteria, a major challenge in developing new antibiotics. The research aims to link...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will fund research to explore the interactions between the human microbiome and the extracellular matrix (ECM) and their impact on tissue remodeling. The $366,438 award, effective September 13, 2024 through June 30, 2029, will enable the research team at the University of Florida to develop in vitro and ex vivo models using...
This Project Grant award of $729,010 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize novel phage lysis proteins and their mechanisms of action. The 5-year project, awarded to Texas A&M University, aims to experimentally elucidate the molecular mechanisms of diverse phage lysis proteins, including those found in phages infecting abundant but understudied human gut microbiota....
This $289,424 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to expand the synthetic biology toolset for natural products discovery from myxobacteria. The long-term objective is to increase the number of heterologous host chassis and develop novel strategies to generate host platforms to utilize biosynthetic gene clusters (BGCs) for discovering new bacterial metabolites with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the molecular and mechanistic bases of biofilm microbial communities. The $550,108 award to the University of California, Merced aims to investigate how transcriptional networks regulate gene expression during biofilm development, including in fungi, bacteria, and archaea that are commensals and/or pathogens of...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 (Biomedical Research and Research Training) provides $759,234 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on host-microbiome coevolution and genetic variation in immunity using an insect model system. The key objectives are to: 1) Understand the evolutionary forces maintaining host genetic variation related to the microbiome and how immune...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,338,750 Project Grant to Yale University to conduct research on how gut bacteria can influence host feeding behavior and microbiome assembly using the roundworm Caenorhabditis elegans as a model system. The project aims to develop tools and assays to study the molecular mechanisms by which gut microbes can manipulate host feeding decisions, with the goal of gaining insights that may apply to other host-microbe systems. Key...
This federal Project Grant award for $1,113,999.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will fund research to elucidate the structure and functions of microbially-derived metallophores (small molecules that bind metals) and their role in modulating microbe-microbe and community interactions within human microbiomes. The research aims to better understand how the human...
This $1,003,736 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research program has two main sub-projects: 1) Investigating epitranscriptomic regulation of gene expression across various bacterial species, and 2) Exploring the regulatory roles of novel...

This $395,701 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of Texas at Austin to investigate the molecular bases of interactions between bacteria and their hosts. The research aims to (1) understand how bacterial competition and host immune responses shape microbiome composition, (2) examine how hosts selectively allow beneficial bacteria to colonize, and (3) determine how intracellular symbiotic bacteria evade host cell destruction. The project leverages experimental models like insect gut microbiomes to provide insights applicable to human health. This 5-year research program builds on the university's prior work developing genetic tools to study bee and Drosophila gut bacteria, enabling detailed interrogation of microbiome dynamics and host-microbe interactions.

Generated 6/17/25, 3:26 AM