This Project Grant award for $179,475 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to define and validate a model for identifying prognostic molecular subphenotypes in pediatric sepsis, and to determine the impact of JAK/STAT inhibition on reversing immune dysregulation in these patients. The research aims to address critical knowledge gaps in the management of immune dysregulation in...
This is a Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award of $186,221 will support research to develop personalized sepsis therapies by integrating high-frequency physiological data and electronic health record data to augment sepsis phenotyping and improve predictive algorithms for detecting bloodstream infections. The overarching goal is to enhance the ability to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate T cell receptor (TCR)-mediated T cell activation in neonatal and pediatric sepsis. The $418,750 award to the Feinstein Institutes for Medical Research will fund research to understand how T cell memory and sepsis affect T cell-antigen presenting cell (APC) interactions and TCR activation, as well as how...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is providing $1,218,750.00 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to conduct research aimed at improving sepsis care through the use of artificial intelligence (AI) and machine learning (ML) methods. The key objectives of this 5-year project are to address...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $479,249.00 to The Washington University to study the molecular mechanisms regulating neutrophil pro-inflammatory activity in sepsis. The key goals are to understand how neutrophil A20 signaling contributes to organ damage in sepsis, and to identify potential therapeutic strategies. The research will employ...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $312,974 to the University of California, San Diego (UCSD) to develop multi-modal foundation models for early detection of sepsis. The key objectives are to: 1) curate large-scale electronic health record (EHR) data for pre-training the foundation models, 2) develop multi-modal transformer models to effectively represent...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $684,206 to the University of Maryland, Baltimore to develop multimodal nanoparticle-based immunotherapies for the treatment of sepsis. The key objectives are to: 1) evaluate the immunomodulatory properties of select nanoparticles to maximize therapeutic efficacy in a sepsis model, 2) identify the cellular and...
This Project Grant award, with a total funding amount of $450,000.00, was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The objective of this 48-month project, which began on July 17, 2024, is to enhance early sepsis decision-making by physicians through the integration of human and artificial intelligence (AI). The key products and services to be delivered include: 1) Creation of a de-identified database...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) totaling $721,728 to the Regents of the University of Michigan. The award period runs from May 12, 2025 to April 30, 2030. The research project aims to evaluate how persistent viral infections, such as cytomegalovirus and Epstein-Barr virus, impact clinical outcomes and response to immunomodulatory therapies in pediatric patients with sepsis. The...
This $403,750 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to unravel the relationships between gut and blood microbial signatures and immune responses in sepsis patients. The research will use a meta-systems approach to integrate gut microbial community profiling, metabolomics, measures of intestinal permeability, and blood microbial signatures with immune phenotypes...