This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) in the amount of $418,750.00 will support research on T cell receptor-mediated T cell activation in neonatal and pediatric sepsis. The project aims to provide insight into how T cell memory influences sepsis-associated organ dysfunction, hypothesizing that dysregulated interactions between immune cells, primarily driven by memory T cell receptor activation, contribute to the pathophysiology of sepsis. The 5-year project will compare T cell-antigen presenting cell interactions and T cell receptor activation in human neonates, pediatric, and adult sepsis patients to understand the influence of T cell memory and sepsis on these immunological processes. The research will further examine how circulating factors, such as components of the renin-angiotensin-aldosterone system, are affected by age and impact T cell receptor activation in sepsis.
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