This $186,221 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop personalized sepsis therapies for pediatric patients. The key objectives are to: Enhance sepsis phenotyping by integrating high-frequency physiologic data with electronic health records to identify additional subtypes and predict disease progression. Retrospectively develop and externally validate...
This $455,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the "Suspect Treat Organ Failure Prevent Sepsis Mortality (STOP Sepsis Mortality)" project at the Children's Research Institute in Washington, D.C. The project aims to decrease pediatric sepsis mortality through three key activities: 1) developing an AI-guided early sepsis identification tool, 2) performing sepsis...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $684,206 to the University of Maryland, Baltimore to develop nanoparticle-based immunotherapies for the treatment of sepsis. The objectives are to evaluate the immunomodulatory properties of these nanoparticles, identify their cellular and molecular mechanisms of action, and determine the optimal therapeutic window...
This National Institute of General Medical Sciences (NIGMS) Project Grant award under CFDA 93.859 (Biomedical Research and Research Training) supports research to investigate the role of T cell receptor (TCR) activation in neonatal and pediatric sepsis. The $418,750 award, effective from January 1, 2025 to November 30, 2029, will be conducted by the Feinstein Institutes for Medical Research, a leading non-profit research organization. The research aims to understand how T cell memory responses...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,583,391.00 to The Regents of the University of California, San Francisco (UCSF) to conduct research on sepsis pathogenesis and treatment. The key objectives are to: Identify known and novel pathogens responsible for septic shock using metagenomic sequencing of host and microbe samples. Discover novel sepsis...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,249 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University located in Missouri. The grant aims to study the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis, which is a leading cause of death in intensive care units. Specifically, the research will investigate how neutrophil A20 signaling contributes to organ damage and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $179,475 over 3 years to The Children's Hospital of Philadelphia Research Institute to define and validate molecular subphenotypes that predict severity in pediatric sepsis, and to determine the impact of JAK/STAT inhibition on reversing immune dysregulation in these patients. The primary objectives are to develop a model to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $195,607 in funding to The Washington University in St. Louis to investigate the role of the ADAM10 protein in the dysregulated host response to pathogens that leads to sepsis. The primary goals are to: 1) Understand the molecular mechanisms by which diverse pathogens activate endothelial ADAM10, 2) Characterize...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support research to investigate the role of endoplasmic reticulum autophagy (ER-phagy) in the inflammatory response during sepsis. The $598,228 award, effective September 5, 2024 through May 31, 2029, will be performed by the University of Illinois in Chicago. The research aims to define the mechanisms by which ER-phagy in macrophages...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $462,000.00 to the University of Rochester to investigate how the human microbiome primes and regulates neutrophil immune responses in sepsis. The key products and services to be delivered under this 2-year award include: Elucidating the mechanisms by which the microbiome differentially primes neutrophils in...