This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $335,712 to the University of New Mexico to develop advanced imaging techniques for studying protein interactions and organizations in cells. The primary objectives are to: 1) Develop high-resolution two-color single-particle tracking (SPT) methods to investigate dimer formation and dissociation, and 2) Create a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $364,969 will fund the development of a toolbox of switchable and functional fluorescent probes for multi-functional super-resolution microscopy (MF-SRM). The overarching goal is to enable new experimental and computational studies in the fields of chromatin epigenetics and spatially-resolved multi-omics by decoding...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,465,164 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois. The grant supports the development of new super-accurate and super-resolved fluorescence microscopy techniques and probes for studying single molecular motors, such as kinesin, dynein, and myosin. Key focus areas include measuring conformational changes in these motors with nanometer and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $410,000.00 to the University of Chicago to conduct an in-depth investigation of bacterial secretion systems using cryo-electron tomography. The key focus areas are: 1) studying the assembly, disassembly, and function of the bacterial flagellar motor, a type III secretion system, and 2) deciphering the role of the type IV...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
This Project Grant award of $630,000 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program will support the development of an advanced optical microscopy system at the University of New Mexico (UNM). The system will combine two recent breakthroughs in imaging techniques - MINFLUX and modal imaging - to enable unprecedented spatiotemporal resolution for studying protein interactions and oligomerization kinetics on living cell membranes. The research will focus...
The National Institute of General Medical Sciences (NIGMS) has awarded a $389,653 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF-SUNY), doing business as Rf-SUNY At The University At Albany. This 5-year project, starting on January 1, 2025, aims to develop a transdisciplinary research program centered around AI-supported biosensing and precision therapeutics using DNA nanotechnology and...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...