Project Grant R35GM156809
- This federal Project Grant award of $374,595.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the impact of controlled 3D topographical design on biological interactions. The award aims to: (1) Develop versatile 3D topographic nanopatterning tools that can accurately replicate dynamic 3D topographies found in natural biological systems; and (2) Develop a suite of 3D model systems...
- This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the commercialization of an automated cell culturing system that addresses limitations of conventional methods. The $295,038 award to Altvivo, Inc. will enable the development of novel capabilities, including 1) inducing different cell lineages from stem cells via localized drug delivery, and 2) real-time,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $389,600.00 to Drexel University to conduct research on the physical mechanisms of 3D cell motility. The project aims to investigate how the structure of 3D extracellular matrices affects actomyosin contractility and water influx, which are essential for cell movement through 3D environments like wound healing and...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $421,600 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered under this 5-year award include: Elucidating genetic and environmental contributions to human cell fitness and growth, leveraging innovative tools such as a...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The $526,451 grant, awarded on May 1, 2025, supports the development of a novel optical microscopy modality for cell biomechanics research based on pulsed stimulated Brillouin scattering (SBS). The goal is to create a non-contact, non-perturbative, and high-resolution system to study the...
This Project Grant award of $385,671 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new 3D printing techniques for creating biomimetic cell culture matrices. The key objectives are to: 1) Investigate the impacts of using visible and near-infrared light versus UV light in digital light processing (DLP) 3D printing on cell viability and metabolism; 2) Determine optimal microscopic mesh sizes and macroscopic pore geometries to facilitate uniform cell morphology and proliferation; 3) Explore how the layered topography of DLP 3D printed structures influences cell adhesion, mobility, and differentiation; 4) Assess cellular responses to sharp versus smooth transitions in mechanical and biochemical cues; and 5) Evaluate individual and combined effects of mechanical and biochemical cues on human mesenchymal stem cells. This 5-year award, starting on September 1, 2025, aims to provide new insights into cell-matrix interactions that can enable more effective in vitro cell culture models and advance disease monitoring, diagnosis, and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $385.7k | 8/26/25 |