Project Grant R35GM156743
- This Project Grant award of $892,050.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Missouri at Kansas City (UMKC) to investigate how plant viruses modulate host chromatin dynamics and gene expression. The key objectives are to: Determine how the PEMV2 virus P26 protein induces chromatin compaction and alters host gene expression, potentially repressing...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), to the University of Pittsburgh. The $634,981 award supports research to investigate the role of Merkel cell polyomavirus (MCV) small T antigen in persistent viral infection. The research aims to understand how MCV gene expression and promoter regulation control viral replication, as well as identify...
- The Regents of the University of Michigan received a $160,448 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on December 12, 2025. The award supports research aimed at determining the structure and protein identity of the stalk component of the Helicobacter pylori Cag Type IV Secretion System (Cag T4SS), mapping connections between the Outer Membrane Core Complex (OMCC) sub-regions, and structurally...
- This $525,095 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify novel cellular determinants of human cytomegalovirus (HCMV) infection. The University of Rochester, the primary awardee, aims to: Elucidate the mechanisms through which the cellular factor JUNB can restrict HCMV infection. JUNB is a stress-induced transcription factor that regulates...
- The Regents of the University of Michigan was awarded a $132,300 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant, titled "The Multifaceted Roles of PI(4,5)P2 on HIV-1 Assembly," will fund research to elucidate the role of the lipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] in HIV-1 assembly and the incorporation of the HIV-1 glycoprotein...
- This federal Project Grant award of $420,984 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how viruses sense and respond to host cell cues in real-time to coordinate their life cycle. The key focus is on studying how host-derived post-translational modifications of viral proteins act as molecular biosensors to enable viruses to adapt to the intracellular environment....
- The University of Michigan received a $183,044 Project Grant from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) to support research on resolving how the Epstein-Barr virus (EBV) oncoproteins EBNA3A and EBNA3C coordinate with the cellular regulator EZH2 to drive lymphoproliferation and pathogenic outcomes in EBV-infected cells. This 3-year grant, awarded on February 3, 2025, aims to provide comprehensive high-resolution insights on vulnerabilities in EBV-driven...
- This Project Grant award, totaling $547,875, was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Stetson University, Inc. in Florida. The funding supports research to identify the unique mechanisms by which the Merkel Cell Polyomavirus (MCPyV) small tumor antigen drives the development of Merkel Cell Carcinoma, an aggressive form of skin cancer. The research utilizes an innovative "dissimilarity approach" to exploit the fact that MCPyV is uniquely...
- The federal Project Grant award of $387,783 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research by The Pennsylvania State University (Penn State) to study the intrinsic dynamics and assembly-disassembly transitions of icosahedral human viruses. The long-term focus of this research is to uncover host-induced changes in pathogenic human viral dynamics, targeting the critical steps of virus entry...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $370,190 to San Diego State University Foundation to conduct research on the molecular mechanisms of viral nucleocapsid self-assembly and disassembly. The research aims to enhance fundamental understanding of these essential steps in the replication of RNA-packaging viruses, which could inform the development of new...
The Regents of the University of Michigan received a $381,853 project grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to investigate the nuclear entry mechanisms of two DNA viruses - the oncogenic Merkel cell polyomavirus (MCPyV) and the oncolytic LuIII parvovirus. Over a 5-year period ending June 2030, the research will use molecular biology, biochemistry, and microscopy techniques to determine how these viruses target and cross the nuclear membrane, as well as identify the host factors required for this process. The goal is to increase the fundamental understanding of viral nuclear entry to advance the diagnosis, treatment, and prevention of virus-associated diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $381.9k | 9/2/25 |