Project Grant F32AI186525
- The Regents of the University of Michigan was awarded a $132,300 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant, titled "The Multifaceted Roles of PI(4,5)P2 on HIV-1 Assembly," will fund research to elucidate the role of the lipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] in HIV-1 assembly and the incorporation of the HIV-1 glycoprotein...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $125,973 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of Michigan. The grant, awarded on February 3, 2025, aims to identify patient and bacterial factors associated with the emergence and spread of resistance to two novel beta-lactam/beta-lactamase inhibitor antibiotic therapies: meropenem-vaborbactam and imipenem-relebactam. The researchers...
- The federal Project Grant award of $189,150 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research to elucidate the molecular mechanisms of the Streptococcus pneumoniae enzyme HtrA and its target interactions. The project aims to investigate the unique structural and functional features of this first family member from the largely unexplored phylogenetic branch of pathogenic Gram-positive...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to determine how the gastric pathogen Helicobacter pylori utilizes ribosomal silencing to regulate its ribosome population and maintain chronic infections. The $168,414 award to the University of California, Santa Cruz will fund a study to investigate the role of the H. pylori ribosome...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award of $123,737.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance drug discovery for protein domains containing intrinsically disordered regions. The award was granted to the Regents of the University of Michigan, a prominent U.S. state government-owned educational institution, with a performance period from October 1, 2024 to April 30, 2025. The NIGMS...
- This federal Project Grant award of $481,250.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on inhibiting lipoprotein synthesis in the bacterium Helicobacter pylori. The goal is to develop new antimicrobial treatments, as H. pylori infections can lead to severe diseases like peptic ulcers and gastric cancer, and antibiotic resistance is increasing. The 2-year project...
- This $492,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to conduct biochemical and structural characterization of the elongasome and divisome protein complexes in Mycobacterium tuberculosis (MTB) and the model organism Mycobacterium smegmatis. The research will use bacterial genetics and endogenous protein purifications to understand how these critical protein systems coordinate and interact to...
- This Project Grant award of $145,593 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research at Yale University to study how Helicobacter pylori infection affects the redox regulation of host ribosomal proteins. The research has two key aims: 1) to elucidate whether ribosome biogenesis and translational function are affected during H. pylori infection, and 2) to characterize how the reactivity of...
- This federal Project Grant award of $2,011,480.00 from the Department of Health and Human Services National Institutes of Health under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research by the Regents of the University of Michigan on enzyme-inspired multimetallic cooperativity. The research aims to address key questions related to how metal ion identity alters electronic structure in multimetallic active sites, how Lewis acid adducts...
The Regents of the University of Michigan received a $160,448 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on December 12, 2025. The award supports research aimed at determining the structure and protein identity of the stalk component of the Helicobacter pylori Cag Type IV Secretion System (Cag T4SS), mapping connections between the Outer Membrane Core Complex (OMCC) sub-regions, and structurally and functionally characterizing actively translocating Cag T4SS. This work will provide the first structural description of the Cag T4SS OMCC and molecular snapshots of translocating T4SS, enabling a structure-based rationale for how the CagA protein is transported from H. pylori into host cells. The project is expected to be completed by June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $80.2k | 6/12/25 | ||
| Not listed | $0 | 6/12/25 | ||
| Not listed | $80.2k | 6/12/25 |