This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is providing $386,843 to The Curators of the University of Missouri (dba University of Missouri at Kansas City) to investigate the mechanisms by which viral biomolecular condensates disrupt cellular translation and RNA interference. Over the next 5 years, the research program aims to: 1) elucidate how viral condensates, particularly the PEMV2...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program, will support the development of a research program focused on using structural homology to uncover and study independently evolved effector proteins in understudied, biodiverse species and the viruses that infect them. Key objectives include defining patterns of gene capture in diverse viruses and identifying structural homologs of...
This $387,783 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to uncover host-induced changes in pathogenic human viral dynamics by targeting the first critical steps of virus entry into human host cells. The primary focus is on studying the intrinsic dynamics of icosahedral viruses, including enveloped RNA viruses like Flaviviruses, non-enveloped RNA viruses like...
This $370,190 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to measure and understand the molecular mechanisms of viral nucleocapsid self-assembly and disassembly. The research will apply quantitative experimental methods, including interferometric scattering microscopy and cryo-electron microscopy, to a diverse set of RNA-packaging viruses. The goal is to uncover potentially...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program provides $500,000 from March 2024 through February 2027 to researchers at the University of Maryland and Silvec Biologics, Inc. to develop methods to stabilize RNA genomes in viruses that can be used as therapies to treat plant diseases. The project aims to use computational approaches, including artificial intelligence, to design RNA structures that can be inserted into virus genomes to increase...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $240,000 to fund a 3-year postdoctoral research fellowship. The research project aims to characterize the diversity of viruses infecting native prairie sunflowers (Helianthus petiolaris) in western grasslands of North America. The research will use virus metagenomics, seed resurrection experiments, and field trials to explore the eco-evolutionary mechanisms governing virus...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research focused on understanding the epigenetic regulation of the HIV-1 viral RNA cap and its linkage to HIV's ability to modulate host immune signaling. The total funding amount is $696,828.00 and the award date is August 14, 2024, with an ultimate completion date of June 30, 2029. The research...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $498,983 to Carthage College to develop two biochemical tools to study Potato Virus Y (PVY) infection in plants. The key products to be delivered include: A synthetic PVY viral clone to facilitate the targeted design of chimeric viruses and identify the genetic determinants of PVY infectivity. An enzymatic reporter probe to enable earlier detection of PVY spread within the host...
The University of Kansas Center for Research Inc. was awarded a $535,860 Project Grant from the National Science Foundation Division of Environmental Biology under the Biological Sciences federal grant program (CFDA 47.074) to conduct collaborative research on systematic viral discovery through structured search of host phylogeny from July 1, 2023 through June 30, 2027. As the prime awardee, the University of Kansas Center for Research will leverage cryogenically frozen tissue collections from...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) aims to advance the understanding of how cellular DNA replication and repair mechanisms are exploited by viral pathogens. The $375,430 award to the University of Wisconsin System, awarded on September 10, 2024, will fund research to interrogate how viruses hijack host genome stability pathways for their own benefit. The project seeks to develop novel tools...