This $387,783 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to uncover dynamics of how pathogenic human viruses, including enveloped RNA viruses (e.g., dengue, Zika), non-enveloped RNA viruses (e.g., coxsackie), and non-enveloped DNA viruses (e.g., human papillomavirus), enter and infect human host cells. The research program will integrate cryo-electron microscopy, structural mass spectrometry, biophysical probes, and RNA chemistry to study the metastable, "breathing" dynamics of these icosahedral viral particles as they transition between assembled and disassembled states to bind receptors, undergo endocytosis, and release their genomes within host cells. This work aims to advance the discovery of therapeutic antibodies and small molecules for improving human health outcomes against viral diseases. The award began on June 1, 2025 and is scheduled for completion on May 31, 2030, with the research to be conducted at Penn State University.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $387.8k | 5/22/25 |