This $403,423 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the molecular mechanisms of antibiotic inhibition of ribosomal subunit joining in bacteria. The project aims to characterize the kinetic, thermodynamic, and structural dynamics of the subunit joining process and elucidate how antibiotics impact these parameters. The research comprises three...
This Project Grant award in the amount of $678,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, which has a project period from April 17, 2025 to March 31, 2030, supports research at Rockefeller University to understand the molecular mechanisms underlying the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $375,420 from June 1, 2025 to April 30, 2030 to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on the structural and functional mechanisms that enable translation factors to monitor the quality and accuracy of protein synthesis in bacteria. The research aims to elucidate how canonical...
This $392,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to mechanistically characterize the enzymology of human ribosome biogenesis. The 5-year project aims to fill a knowledge gap in understanding the molecular mechanisms underlying ribosome biogenesis, which is among the most energetically costly cellular processes and is dysregulated in ribosomopathies and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $421,999 to Emory University to investigate mechanisms of RNA localization and centrosome regulation. The research aims to determine how local RNA directs centrosome function and activity, particularly regarding cell cycle-dependent oscillations in RNA enrichment, conserved regulatory paradigms, and novel regulators. The...
This federal Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $406,250 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to conduct research on the dynamics of RNA regulation and non-canonical translation between cell states. The research aims to map post-transcriptional gene expression, focus on...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $584,420.00 to the Albert Einstein College of Medicine to investigate the role of protein motions associated with intrinsic disorder and their specific functions. The project aims to gain a deeper understanding of the nuclear pore complex and how flexible proteins facilitate the transport of biomolecules in and out of the...
This $1,003,736 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research program has two main sub-projects: 1) Investigating epitranscriptomic regulation of gene expression across various bacterial species, and 2) Exploring the regulatory roles of novel...
This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The research program aims to investigate the molecular mechanisms that control 2',3'-cyclic nucleotide monophosphate (2',3'-cNMP) signaling in bacteria, including its effects on transcription,...
This $1,612,448 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance the understanding of mRNA splicing mechanisms and their impact on biological function. The key objectives are to: (I) develop computational methods for studying RNA splicing in human biology and disease, (II) characterize how splicing regulates gene expression levels, and (III) investigate...