This $820,000 Project Grant was awarded on July 15, 2023 by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant supports a collaborative research effort involving four research labs, two in the U.S. and two in Israel, to investigate RNA editing enzymes called ADARs (Adenosine Deaminases Acting on RNA). The goal is to advance the understanding of how ADAR enzymes can be used by different organisms to...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This $328,000 federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and application of an RNA editing platform called TRIBE-ID. The platform will be used to investigate dynamic RNA-protein interactions in cells, with the goal of advancing the understanding of RNA regulatory mechanisms and accelerating the development of RNA-targeted therapeutics....
This $230,312 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate RNA interference and related gene regulatory mechanisms in the model organism C. elegans. The research aims to address three key questions: 1) how cells distinguish licensed from potentially dangerous unlicensed information, 2) how Argonautes and chromatin regulators coordinate to propagate...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $729,006 over a period of 5 years starting January 14, 2025 to study how the adenovirus manipulates host RNA binding proteins to support viral infection. The research will employ advanced proteomics and imaging techniques to define the mechanisms by which the adenovirus alters RNA-protein complexes and evades...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) aims to develop innovative technologies to investigate the role of ADP-ribosylation, an under-studied DNA modification implicated in critical biological processes. The $204,688 award to The Johns Hopkins University will support the development of two complementary sequencing techniques to pinpoint DNA ADP-ribosylation sites across the genome, using...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This federal Project Grant award, R35GM153238, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $890,066 award, effective from Sep 2, 2024 to Jul 31, 2029, supports research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for controlling gene expression patterns during embryonic development and in...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $420,744 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to Oregon Health & Science University (OHSU). The purpose of this 2-year award, with a performance period from June 1, 2025 to May 31, 2027, is to develop a methodology for simultaneously analyzing adenosine-to-inosine (A-to-I) RNA editing in targeted transcripts and...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...