This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program is focused on deepening the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The $1,050,000 award to The Trustees of Princeton University, spanning from February 2025 to January 2028, will support research to characterize the dihydrouridine (D) RNA modification and the enzymes that mediate its installation. The project...
This Project Grant award, valued at $412,525.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research focused on the molecular mechanisms that regulate ADAR target recognition and RNA editing. The award will fund an integrated research approach using human cell lines and the model organism Caenorhabditis elegans to investigate how ADAR binding to target RNAs is influenced by...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,102,648 to The Trustees of Columbia University in the City of New York, doing business as Columbia University, to conduct research on how the dynamic molecular interactions of RNA-binding proteins (RBPs) drive post-transcriptional gene expression changes during embryonic stem cell differentiation. The research aims to globally map...
This $1,084,158 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the University of Michigan's research efforts to investigate RNA-protein interactions (RPIs) and develop enabling technologies. Specifically, the grant funds three major research directions: 1) Further development of the university's live-cell RPI assay technology, RNA Interaction with Protein-mediated Complementation Assay...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at Northwestern University on how RNA modifications regulate translation initiation and cellular stress responses. The $440,000 award, effective August 1, 2025 through May 31, 2030, will integrate biochemistry, chemical biology, transcriptomics, and cell biology approaches to investigate how the epitranscriptome...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $812,500 in funding to The Trustees of the University of Pennsylvania (UPenn) to conduct research on RNA regulation and noncanonical translation between cell states. The research aims to map post-transcriptional regulation and the unannotated proteome, including RNA localization and modifications, to better understand how...
This Project Grant award, with ID R01GM157259, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, totaling $337,088, supports the development of a versatile platform for RNA delivery specifically tailored for the central nervous system (CNS). The key objectives are to establish a delivery system capable of high-efficiency RNA transfer, precise cell-specific targeting, and minimal...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $350,000 to Electronic Biosciences, Inc. to develop a novel technology for high-accuracy sequencing of pseudouridine (Ps) and N6-methyladenosine (M6A) RNA modifications. The project aims to merge Professor Cynthia J. Burrows' bisulfite adduct methodology with Electronic Biosciences' nanopore sequencing platform to create the first sequencing...
This Project Grant award, totaling $432,834, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award supports the development of an "enzyme-free, label-free quantitative microarray technology" to enable highly sensitive and quantitative measurement of small nucleic acid targets, such as microRNAs, with applications in liquid biopsy diagnostics. The research strategy...