Project Grant R35GM156238
Award Date
6/1/25
Completion Date
3/31/30
Dollars Obligated
$598K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43210, USA
Similar Awards
This $322,962 project grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to uncover the link between prions and BAF protein complexes and their role in transcription regulation and cellular phenotypes. Key objectives include: Characterizing variants of the [SWI+] prion and their distinct transcriptomic and phenotypic effects. Examining how [SWI+] alters the structure and activities of the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $584,420.00 to the Albert Einstein College of Medicine to investigate the role of protein motions associated with intrinsic disorder and their specific functions. The project aims to gain a deeper understanding of the nuclear pore complex and how flexible proteins facilitate the transport of biomolecules in and out of the...
This federal Project Grant award of $402,500.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to advance the understanding of single-strand break (SSB) repair mechanisms within chromatin. The key products and services to be delivered under this 5-year grant, awarded on July 15, 2024, include: Mapping the accessibility of SSB sites within nucleosomes using DNA libraries and next-generation...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $459,006.00 to Marquette University for a research project titled "Understanding the Role of Molecular Chaperone Systems in Protein Aggregate Disassembly" over the period of July 1, 2024 to June 30, 2027. The objective of this project is to define how two different chaperone systems, HSP110 and HSP104, work...
This $392,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to mechanistically characterize the enzymology of human ribosome biogenesis. The 5-year project aims to fill a knowledge gap in understanding the molecular mechanisms underlying ribosome biogenesis, which is among the most energetically costly cellular processes and is dysregulated in ribosomopathies and...
This $360,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate biological mechanisms for proton transfer. The goal is to design and characterize photoacid-binding proteins that can be used to spectroscopically study proton dynamics in biological systems. Key activities include computationally designing protein scaffolds to bind photoacid cofactors,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $410,000.00 over 5 years to support research by The Trustees of Princeton University on the molecular structures and interactions that sustain biomolecular condensates, with a focus on stress granules. The research aims to develop accurate and efficient computational models to characterize the molecules within stress...
The National Institute of General Medical Sciences (NIGMS) awarded a $450,313 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University to conduct research on the molecular mechanisms that regulate dynamic multidomain protein complexes, particularly nonribosomal peptide synthetases (NRPS). The project aims to leverage nuclear magnetic resonance (NMR) spectroscopy and computational approaches to determine the structural ensembles that govern NRPS...
This federal Project Grant award for $1,207,500.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant aims to enable the development of programmable, isoform-selective proteome editing systems using generative artificial intelligence approaches. The key research objectives are to: 1) enable peptide-guided protein stabilization and deubiquitination, 2) develop methods for mutant-specific...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $275,100 to fund research focused on understanding the structure and function of proteins involved in intracellular transport within human cells. The research will utilize nuclear magnetic resonance (NMR) spectroscopy and other biophysical methods to investigate how structurally disordered regions of proteins, such as the dynein...