This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Pittsburgh over a 5-year period from September 2024 to August 2029. The research aims to develop advanced computational and machine learning models that integrate diverse biomedical data, from genetics to transcriptomics and proteomics, to better predict the effects of therapies on diseased cells....
The National Institute of General Medical Sciences (NIGMS) awarded a $1,335,099 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of Chicago. The 5-year award, effective September 2, 2024, will support research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for gene expression control and have implications for human health. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $359,490 to the University of Florida to develop a suite of deep learning methods for "Single-Cell Genetics". The goal is to integrate cutting-edge single-cell genomic data into genetic analysis to address challenges in disease genetics, including variant interpretation, gene discovery, cell prioritization, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $222,708.00 to the Massachusetts Institute of Technology (MIT) to conduct research on the mechanistic basis of individual and clustered enhancers in human cells. The goal is to gain a comprehensive and quantitative understanding of how dynamic enhancer-promoter interactions regulate transcription in different cell...
This federal Project Grant award of $536,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop computational methods that can better identify and analyze rare cell populations from single-cell transcriptomic data. The project, titled "A Knowledge-Guided Analysis Approach to Recovering Rare Signals from Single-Cell Transcriptomic Data," will be conducted by the Sanford...
This Project Grant award of $129,708 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of advanced computational tools for analyzing single-cell data. The goal is to provide new methods for modeling and interpreting complex cellular processes like differentiation and disease progression, with a focus on applications in hematopoiesis, tissue regeneration, and large-scale perturbation studies....
This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to develop improved computational methods for human gene annotation. The $387,500 award to The Johns Hopkins University will fund efforts to adapt and expand their existing StringTie software system, a genome-guided transcriptome assembler, to process large-scale RNA sequencing data and build a comprehensive,...
This $713,180 project grant, awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program, aims to develop an innovative computational framework for identifying context-specific enhancer targets in mammalian genomes. The three-year project at the University of Central Florida has three main objectives: 1) creating computational methods and tools to predict known enhancer targets in new samples, 2) developing approaches to predict novel enhancer targets, and 3)...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) totals $408,750 and is effective from September 15, 2024 through July 31, 2029. The award will support the development of large-scale composite hypothesis testing approaches for performing translational genetics analyses. Specifically, the research will focus on creating interpretable and robust statistical methods for...
This federal Project Grant award of $142,065 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of computational frameworks to model the impact of external signals on a cell's internal transcription factor activity. The key products and services to be delivered under this award include: Computational methods to more accurately deconvolve cell type fractions and gene expression from bulk RNA-seq and spatial transcriptomics data. A...