This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) totaling $408,750.00 will support the development of large-scale composite hypothesis testing approaches to perform translational genetics analyses at The University of Texas MD Anderson Cancer Center. The goal is to create interpretable and robust statistical methods for identifying genetic variants linked to multiple diseases simultaneously, testing for genetic mediation, and replicating genetic associations - areas of significant importance for translational genetics research. Successful completion of this work will result in novel software packages to be shared with the research community, along with the release of summary data from the analysis of varied phenotypes. This award will further enhance MD Anderson's extensive cancer research capabilities across basic, translational, clinical, and public health domains, which are supported through a range of federal prime and subaward funding.
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