The National Human Genome Research Institute (NHGRI) awarded a $142,065 Project Grant under the Human Genome Research program (CFDA 93.172) to Yale University. The grant supports the development of computational frameworks to model the impact of external signals on transcription factor activity using single-cell multiome and spatial transcriptomics data. The aim is to advance the identification and understanding of cell-cell interactions, which play crucial roles in biological processes like inflammation and cancer. The project will create a suite of tools, including DeepPrism, SpaceNiche, RegulatoryVAE, NicheOT, and CARCell, to deconvolve cell type-specific gene expression, infer transcription factor activity, and quantify the impact of cell-cell interactions. These methods will be applied to study inflammatory bowel disease using data provided by a collaborator. The grant has an award date of Sep 23, 2024 and an ultimate completion date of Aug 31, 2026.
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