The National Institute of General Medical Sciences (NIGMS) awarded a $1,132,500 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Medical University of South Carolina (MUSC). The grant, effective September 1, 2024 through June 30, 2029, will support research to unravel the complex interactions between gut microbiota and intestinal mucus. The project aims to investigate the mechanisms by which gut bacteria respond to and stimulate mucus production,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $422,931 to characterize the role of specialized microbial metabolites in mediating interactions within the human microbiome. The award aims to integrate cheminformatics analysis of metabolomics data with in vitro model systems to elucidate novel chemistry that influences the structure and function of the microbiome, including...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,338,750 Project Grant to Yale University to conduct research on how gut bacteria can influence host feeding behavior and microbiome assembly using the roundworm Caenorhabditis elegans as a model system. The project aims to develop tools and assays to study the molecular mechanisms by which gut microbes can manipulate host feeding decisions, with the goal of gaining insights that may apply to other host-microbe systems. Key...
The National Institute of General Medical Sciences (NIGMS) awarded a $367,105 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Wisconsin - Madison to support research on regional extracellular matrix (ECM) remodeling. The research program aims to increase the rigor and reproducibility of approaches for capturing ECM heterogeneity and its influence on tissue load-bearing function. Key focus areas include developing improved methods for visualizing ECM...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,136 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The five-year grant, effective May 1, 2025 through March 31, 2030, supports research to define engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells. The goal is to develop these probioms, modeled after natural probiotic...
The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,759,395.00 over 5 years to the University of Oregon to investigate the assembly, function, and health impacts of social microbiomes. The award supports a multidisciplinary research program that aims to establish a new field of study on how social interactions and associated microbial communities (social microbiomes) shape host health...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $395,701 to the University of Texas at Austin to investigate the molecular bases of interactions between bacteria and their hosts within microbial communities. The research aims to better understand how microbial communities are shaped and how they affect their hosts, using insect models like bees and Drosophila. Key...
This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $444,830 to the University of Florida to develop novel small molecule probes to detect heparanase activity and explore the precise function of heparanase in extracellular matrix (ECM) remodeling. The 5-year project aims to build a library of structurally-defined heparanase probes and utilize them in in vitro and in vivo models to...