This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $162,874 to The Trustees of Princeton University to conduct research on the regulation of protein dynamics in the ectoderm germ layer of Drosophila embryos. The key objectives are to: Quantify proteome differentiation and stochastic cell fate diversification using deep multiplexed proteomics and single-cell RNA sequencing (Aims...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,173 to the University of Massachusetts Boston to advance understanding of cellular signaling networks controlling organism development. The research aims to investigate three signaling systems that regulate key developmental processes of organ growth and tissue patterning. Specifically, the project will study...
This $335,504 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a systems-level analysis of the dynamics and regulation of the Drosophila NF-kappa B/Dorsal signaling module. The central objective is to use systems biology modeling and quantitative live-cell imaging to build a predictive model of the Dorsal gradient, which patterns the dorsal-ventral axis in early Drosophila embryos. The key...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,061,192 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Genetivision Corporation in Stafford, TX. The grant, which runs from July 2025 to June 2027, will fund the generation, validation, and maintenance of 2,400 conditional loss- and gain-of-function alleles for over 1,200 highly conserved Drosophila genes. This new collection of precisely controllable genetic tools will enable researchers to...
This federal Project Grant award, valued at $423,500.00 and granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program focused on understanding the genetic basis and molecular mechanisms of evolutionary conflicts and hybrid incompatibilities. The key objectives of this 5-year research project, which commenced on May 1, 2025, are to: Elucidate the molecular mechanisms underlying the...
This National Science Foundation Project Grant award of $1,324,710 provides funding from July 1, 2022 through June 30, 2025 to support research understanding how newly evolved genes acquire protein interactions and regulatory mechanisms in Drosophila reproduction. Funded under the Biological Sciences program (CFDA 47.074), the award to the College of the Holy Cross will explore how three genes essential for Drosophila melanogaster spermatogenesis evolved novel capabilities, including physical...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship focused on modeling gene drive with selfish germline stem cells in the Drosophila testis. The key products and services to be delivered through this 3-year project include: Identification of Chinmo protein binding sites on chromatin and Chinmo transcriptional targets in germline stem cells (GSCs) using CUT&RUN and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $507,000.00 in funding to the University of California, Davis to conduct research on evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila. The key objectives are to: 1) identify transcriptome novelties in Drosophila melanogaster reproductive tissues and investigate their functions,...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded a $410,000 Project Grant to The University of Texas Southwestern Medical Center (UT Southwestern) for a 5-year research program focused on the evolutionary diversification of cytoskeletal proteins. The grant aims to gain molecular insights into how the actin-related protein (ARP) superfamily has evolved tissue-specific functions, particularly in the...
This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...