This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,173 to the University of Massachusetts Boston to advance understanding of cellular signaling networks controlling organism development. The research aims to investigate three signaling systems that regulate key developmental processes of organ growth and tissue patterning. Specifically, the project will study...
This $198,724 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, Santa Cruz on the functional genetic basis of the symbiotic relationship between the Wolbachia bacteria and Drosophila fruit flies. The overarching goal is to develop a robust understanding of the evolutionary genetics and functional mechanisms underlying this host-symbiont...
This federal Project Grant award for $361,250 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to determine the multifunctional roles of proteins involved in animal development and human health. The principal investigator will use the Drosophila melanogaster model organism to investigate the secondary functions of the abnormal spindle (Asp) protein, which is implicated in microcephaly, cancer, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $507,000.00 in funding to the University of California, Davis to conduct research on evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila. The key objectives are to: 1) identify transcriptome novelties in Drosophila melanogaster reproductive tissues and investigate their functions,...
This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
This is a $1,200,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the Texas A&M Engineering Experiment Station (Tees) for the period of September 1, 2024 to August 31, 2028. The grant supports research to understand how common biological signaling pathways like the Bone Morphogenetic Protein (BMP) pathway can be both widely used and flexible to meet the needs of different tissues across the animal kingdom. The project involves...
This $565,826 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research conducted by Duke University to investigate the signaling and gene regulatory mechanisms that enable nematodes (C. elegans) to adapt to fluctuations in nutrient availability. The research aims to elucidate a conserved network of tumor suppressors that govern the starvation response, with goals including...
This Project Grant award for $509,982.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research conducted by the University of Maryland, College Park to unravel the fundamental mechanisms governing cell-cell communication and signal exchange during animal development. The research aims to characterize a novel "direct delivery" mechanism of extracellular signal...
The University of Arkansas, Fayetteville Division, is the recipient of a $436,326 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project, titled "DISSECTING CRYPTIC GENETIC VARIATION UNDERLYING COMPLEX TRAITS IN DROSOPHILA", aims to use the Drosophila model organism to reveal cryptic genetic variation and uncover novel gene-gene and gene-environment interactions...
This Project Grant award of $184,388 from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Irvine to uncover genetic and other factors influencing infection resistance, survival, and tolerance. The project aims to develop bioluminescence imaging tools to enable real-time, longitudinal monitoring of infection progression and host immune responses in fruit flies (Drosophila). This will allow identification of genetic...
This $335,504 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a systems-level analysis of the dynamics and regulation of the Drosophila NF-kappa B/Dorsal signaling module. The central objective is to use systems biology modeling and quantitative live-cell imaging to build a predictive model of the Dorsal gradient, which patterns the dorsal-ventral axis in early Drosophila embryos. The key research aims include determining the functional role of the Cactus protein in regulating the Dorsal signaling gradient, examining the impact of the Cactus negative feedback loop, and developing a predictive mathematical model of the signaling dynamics. A sub-award of $500,661 was provided to North Carolina State University to collaborate on this systems-level analysis of the Drosophila NF-kappa B pathway. This research is expected to lead to a detailed, mechanistic understanding of NF-kappa B signaling regulation that can be applied to vertebrate systems.