Project Grant R35GM156267

Award Date 5/1/25
Completion Date 3/31/30
Dollars Obligated $424K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Utah, USA
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  1. Investigating the mechanisms of hybrid male lethality between Drosophila melanogaster and related species, focusing on the role of rapidly evolving DNA damage response and cell cycle checkpoint pathways.

  2. Elucidating the molecular drivers of meiotic drive and hybrid sterility in young Drosophila pseudoobscura subspecies, involving the discovery of male germline checkpoints and rapidly evolving non-coding RNAs.

  3. Determining the genetic and molecular basis of meiotic drive by the selfish sex-ratio chromosome in D. pseudoobscura, including the involvement of rapidly evolving meiotic cohesin and dynein proteins.

This five-year research program, commencing on May 1, 2025, aims to integrate evolutionary genomics and cell/developmental biology to advance fundamental understanding of genome evolution and speciation.

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