The University of California Irvine will use a $2.83 million project grant from the Department of Health and Human Services' National Institute of General Medical Sciences to decipher the mechanism of long-range gene regulation in vivo. Over a three-year period ending August 2025, UC Irvine researchers will utilize efficient enhancer replacement technology in mice to systematically characterize long-range enhancer activity and identify cis-regulatory sequences critical to this function. A multidisciplinary approach will map and visualize enhancer-promoter contacts at high resolution to determine the mechanism of long-range regulation by remote control elements and identify regulatory proteins that bind them. This work will expand the repertoire of known cis-regulatory elements, provide a novel general mechanism for long-range enhancer-promoter communication, and substantially advance understanding of three-dimensional genome organization in the context of development and disease. The grant is funded through NIGMS' Biomedical Research and Research Training program (CFDA 93.859), which supports basic research increasing biological process understanding and laying the foundation for advances in diagnosis, treatment and prevention.
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