The National Institute of General Medical Sciences (NIGMS) awarded a $406,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, with a performance period from January 22, 2025 to December 31, 2029. The grant aims to develop new chemistries and engineering approaches to manipulate the dynamic nascent extracellular matrix within complex...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program will provide $1,286,156 to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, from September 1, 2024 to August 31, 2029. The grant will support advanced research on cytokinesis, the septin cytoskeleton, and their roles in fundamental cellular processes and disease...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,218,750 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant, with a period of performance from Sep 1, 2024 to Jun 30, 2029, will fund the development of new biomaterial platforms and bioorthogonal chemistries to study cellular mechanosensing and...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,681 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park (UMD) on February 1, 2025. The grant supports the development of two novel force nanoprobes to map intracellular forces in the genomes of living cells. The first nanoprobe will provide direct quantitative measurements of intracellular forces by converting mechanical stress into...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $335,712 to the University of New Mexico to develop advanced imaging techniques for studying protein interactions and organizations in cells. The primary objectives are to: 1) Develop high-resolution two-color single-particle tracking (SPT) methods to investigate dimer formation and dissociation, and 2) Create a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $411,250 to The Trustees of Columbia University in the City of New York to conduct research on the interactions between membrane-bound organelles, such as lysosomes, and membrane-less organelles, such as RNA granules. The overarching goal is to understand how these two types of cellular compartments coordinate to maintain RNA...