This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of the epidermal integrin A3β1 in age-related declines in cutaneous wound healing. The $216,205 award to Albany Medical College aims to determine how waning A3β1 function in aging skin contributes to impaired wound re-epithelialization and reduced immune...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $623,589 to Childrens Hospital Medical Center in Cincinnati, OH to study the role of the Aryl Hydrocarbon Receptor (AhR) in the development and progression of eosinophilic esophagitis (EoE). The research aims to elucidate how AhR mediates both protective and detrimental effects on esophageal epithelial...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to study the role of the aryl hydrocarbon receptor (AhR) pathway in suppressing T-bet+ B cells in systemic lupus erythematosus (SLE). The $555,774 award will be used to investigate two key questions: 1) whether IL-4 acts through the AhR pathway to inhibit the development of double negative 2 (DN2) B cells, and 2) how...
This three-year, $3.13 million project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research at Michigan State University investigating the progression of non-alcoholic fatty liver disease. Specifically, the grant will test the hypothesis that activation of the aryl hydrocarbon receptor by environmental contaminants reprograms fatty acid metabolism, causing the accumulation of toxic lipid intermediates that contribute to...
This federal Project Grant award in the amount of $202,245 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports a research project at Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center, to investigate the role of intestinal epithelial permeability and the aryl hydrocarbon receptor (AhR) in regulating gut immune tolerance. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on understanding the mechanisms of increased intestinal epithelial cell (IEC) barrier permeability in peanut allergy. The $202,314 grant supports a 5-year research and career development program for Dr. Erin Steinbach, a tenure-track Assistant Professor at the University of North Carolina (UNC) School of...
This $211,590 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research investigating the contribution of the APOM/S1P signaling axis to podocyte injury, which is an emerging pathway contributing to the progression of glomerular diseases of metabolic and non-metabolic origin. The project aims to 1) investigate if...
This Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to elucidate the neuroenteric mechanism by which the hormone ghrelin confers radioprotection to the gastrointestinal system and to develop human ghrelin as a countermeasure for gastrointestinal acute radiation syndrome. The $586,240 award to the Feinstein Institutes for Medical Research will fund research to characterize ghrelin's...
This $715,180 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to understand the epigenetic regulation of trained immunity in thoracic aortic aneurysms and dissections (ATAAD). The project aims to determine the sites and mechanisms of immunity training in monocytes/macrophages, and the role of the STING-IRF3/IRF4 pathway in driving pro-inflammatory macrophage phenotypes during ATAAD...
This $597,518 Cooperative Agreement award, granted by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), supports the Sloan-Kettering Institute for Cancer Research's research to develop an anti-ceramide antibody as a countermeasure against gastrointestinal acute radiation syndrome (GI-ARS) and delayed effects of acute radiation exposure (DEARE). The proposed studies aim to demonstrate how protecting the intestinal...