The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
This federal Project Grant award, ID K23AI182464, was provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Yale University for $194,911.00. The project aims to optimize equitable peanut allergy prevention among high-risk infants through a multi-phase study. Key activities include: Exploring sociodemographic determinants of peanut introduction in high-risk infants. Examining facilitators and barriers to guideline...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $151,444 to The Children's Hospital of Philadelphia (CHOP) to study the development of pediatric allergic diseases and create allergy prediction models using electronic health record (EHR) data. The overarching goal is to improve outcomes in pediatric allergy by understanding the heterogeneous "allergic...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $242,310 to Yale University to conduct research aimed at elucidating the cellular and molecular mechanisms governing the catabolism (breakdown) of immunoglobulin E (IgE). The research project seeks to uncover the receptors and cell types responsible for IgE clearance, as well as the impact of IgE glycosylation on its...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $101,577 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Michigan State University (MSU) to investigate the mechanisms by which early life adversity alters mast cell programming and inflammatory activity through modulation of cholesterol metabolism. The research aims to define how early life stress developmentally heightens the mast cell pro-inflammatory phenotype, which...
This federal Project Grant award of $828,775, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to study the role of food sensitization in the development of cardiovascular disease. The primary awardee, the University of North Carolina at Chapel Hill, will comprehensively assess the relationship between food-specific IgE antibodies and cardiovascular disease mortality,...
This $797,735 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the cellular and molecular mechanisms governing heightened immune responses in neonates. The research project will utilize a novel mouse model to investigate how the innate immune system detects and mediates sterile inflammation during early life development, with the goal of developing targeted...
The federal Project Grant award, identified as F32AI186362, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, totaling $248,088.00, will be used by The Johns Hopkins University to study the role of immunoglobulin E (IgE) and galectin-3 in the activation of basophils, which are key cells involved in allergic reactions. The research aims to compare galectin-3-dependent basophil...
This Project Grant award, valued at $242,310.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research conducted by Weill Medical College of Cornell University to investigate how the early-life intestinal microbiome and maternal antibodies influence the trafficking of commensal microbes to the thymus, which is critical for the development of the...