Project Grant R34NS137184
- This Project Grant award of $621,065 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of advanced genetically encoded voltage indicators (GEVIs) optimized for two-photon microscopy. The goal is to create GEVIs with improved sensitivity for detecting subthreshold signals and enhanced response kinetics to reliably capture rapid action potentials...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
- This $257,750 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop a comprehensive toolkit of genetic tools to identify, label, and manipulate specific cell types in the Drosophila visual system. The project will leverage single-cell mRNA sequencing and single-nucleus RNA/ATAC-seq data to generate...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- This $1,071,930 federal Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) aims to understand how the primate brain's ventral visual stream implements "analysis by synthesis" - a theory of how the visual system coherently perceives scenes by reconstructing them from higher-level models. The principal investigators, an expert in macaque ventral stream electrophysiology and an expert in dynamical systems modeling, will use Neuropixels probes to...
- The Project Grant award of $254,250 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at New York University School of Medicine to develop genetic approaches for studying the organization and function of neocortical layer 1. This research aims to enhance understanding of how top-down and bottom-up information streams are integrated in the brain,...
- The Project Grant award titled "Homeostatic Maintenance of Neocortical Excitation-Inhibition Balance by Ciliary Neuropeptidergic Signaling" was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $290,688 award will support research conducted by Brandeis University to investigate the role of primary cilia in regulating the balance of excitation...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $551,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California, Los Angeles (UCLA) to support research focused on understanding the molecular mechanisms underlying the formation of synaptic connections between neurons in the brain. The key research aims are to uncover the molecular basis of synaptic specificity in the...
- This three-year Project Grant from the National Science Foundation's Division of Integrative Organismal Systems, totaling $550,000, will fund research examining corticocortical communication in the brain under different network states. The Trustees of the University of Pennsylvania, operating as the Clinical Practices of the University of Pennsylvania, will investigate how visual responses are transmitted between local networks in layers 2-3 of primary visual cortex when the brain is in gamma...
- This federal Project Grant award from the National Eye Institute (NEI), part of the Department of Health and Human Services, provides $719,012 in funding to the University of California, Davis to conduct research on optimizing the delivery of adeno-associated virus (AAV) gene therapies via the suprachoroidal space in non-human primates for the treatment of retinal diseases. The goal is to enhance the biodistribution, cellular tropism, durability, and safety of suprachoroidal AAV administration...
CROSS-SPECIES CONSERVATION OF INHIBITORY CELL TYPE CONTRIBUTIONS TO VISUAL CORTICAL FUNCTION - PROJECT SUMMARY THE FUNCTION OF THE NERVOUS SYSTEM IS DEPENDENT ON COMPLEX INTERACTIONS BETWEEN NETWORKS OF NEURONS COMPOSED OF MULTIPLE NEURON TYPES. UNDERSTANDING HOW THESE NETWORKS FUNCTION BOTH IN HEALTH AND DISEASE IS DEPENDENT ON UNDERSTANDING THE PRECISE CONNECTIVITY BETWEEN SPECIFIC NEURON TYPES AND THEIR FUNCTIONAL INTERACTIONS IN THE INTACT BRAIN. IT IS THEREFORE APPARENT THAT, IN ORDER TO HAVE AN ADEQUATE UNDERSTANDING OF THE NERVOUS SYSTEM, IT IS NECESSARY TO HAVE DETAILED DESCRIPTIONS OF NEURONAL CONNECTIVITY WITH THE SAME LEVEL OF PRECISION AT WHICH THESE SYSTEMS OPERATE AND TO SELECTIVELY MANIPULATE AND MEASURE THE ACTIVITY OF SPECIFIC CELL TYPES IN THE CONTEXT OF THE NORMAL FUNCTIONING NETWORK. SUCH STUDIES WOULD BE GREATLY FACILITATED BY THE ABILITY TO TARGET GENE EXPRESSION TO SPECIFIC CELL TYPES IN THE CONTEXT OF AAV VECTORS. THE AIMS OF THIS PROPOSAL ARE DESIGNED TO FIRST TEST AND OVERCOME POSSIBLE LIMITATIONS IN THE USE OF AAV VECTORS TARGETING GENE EXPRESSION TO SST- AND PV-EXPRESSING INHIBITORY INTERNUEON IN THE VISUAL CORTEX, AND THEN TO USE THESE TOOLS TO SELECTIVELY MANIPULATE THE ACTIVITY AND CHARACTERIZE THE FUNCTIONS OF THESE INHIBITORY SUBCLASSES. THE ESTABLISHMENT OF THE UTILITY OF THESE REAGENTS WILL ALLOW FUTURE STUDIES TESTING THE FUNCTIONAL CONTRIBUTIONS OF SPECIFIC INHIBITORY NEURON TYPES TO PERCEPTION,COGNITION AND BEHAVIOR.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $42.8k | 7/11/25 | ||
| Not listed | $384.8k | 6/27/25 | ||
| Not listed | $384.8k | 6/27/25 | ||
| Not listed | $427.5k | 7/9/24 |