This three-year Project Grant from the National Science Foundation's Division of Integrative Organismal Systems, totaling $550,000, will fund research examining corticocortical communication in the brain under different network states. The Trustees of the University of Pennsylvania, operating as the Clinical Practices of the University of Pennsylvania, will investigate how visual responses are transmitted between local networks in layers 2-3 of primary visual cortex when the brain is in gamma oscillation and asynchronous irregular states. Using electrophysiological, optogenetic, pharmacological, and computational approaches, the researchers will quantify cellular and network communication in vivo to understand population dynamics for information transmission. Insights gained from this work could help explain cognitive disorders involving faulty inter-cortical signaling. This award supports the Biological Sciences program's goal of increasing knowledge of major problems through basic biological research.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $550.0k | 9/1/22 |