Project Grant R34CA287718

Award Date 9/4/24
Completion Date 8/31/27
Dollars Obligated $310K
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Louisville, KY 40292, USA
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The National Cancer Institute (NCI) awarded a $257,415 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to The Research Foundation for the State University of New York (RF SUNY) to develop an AI-enhanced smartphone app-based intervention for adolescent e-cigarette cessation. The goal is to create a scalable, cost-effective intervention that uses AI-assisted user profiling and personalized content to help adolescents quit e-cigarettes. The 3-year project will...
The National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) awarded a $247,433 Project Grant to the University of Nebraska Medical Center (UNMC) for the "Parents Helping Parents for Youth Vaping Cessation (PHP-VX)" program. The goal of this feasibility study is to develop and test a parent-facilitated youth vaping cessation intervention, which will include online training sessions and weekly parent-to-parent support. A key sub-award of $34,102 was made to the...
This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to the Regents of the University of California, San Francisco will provide $692,872 to develop and evaluate a scalable social media-based vaping cessation program for adolescents. The project, titled "Social Media Support Groups for Adolescent Vaping Cessation," will adapt the existing "Quit the Hit" program into a toolkit (QTHT) that can be implemented...
This federal Project Grant award of $619,175 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports a Type 1 hybrid effectiveness-implementation trial to evaluate a novel harm reduction approach for oncology outpatients who smoke but refuse traditional tobacco treatment. The study will directly compare rates of switching from cigarettes to e-cigarettes against standard care, while also assessing key barriers and facilitators to implementation. The...
This Project Grant award, funded by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program, supports a research project to identify key features of e-cigarette-related social media posts that are associated with high user engagement. The goal is to provide guidance for designing effective vaping prevention messages for future public health campaigns to help communicate the risks of e-cigarette use and prevent youth and young adult initiation...
The National Cancer Institute (NCI) awarded a $1,698,536 Project Grant (CFDA 93.393 - Cancer Cause and Prevention Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop and test a remote, young adult lay-counselor delivered behavioral and digital intervention called "QuitVaping" to promote nicotine vaping cessation and prevent escalation of tobacco use among youth aged 14-18. The project will enroll 300 adolescents who vape...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will fund a randomized controlled trial to examine the efficacy of a smartphone app called "Kick-Nic!" for e-cigarette cessation among 306 high school adolescents. The app provides an engaging, multimedia-rich, and interactive cognitive-behavioral therapy platform to help adolescents develop coping skills for e-cigarette-specific triggers and support their cessation efforts....
This Project Grant award from the National Institutes of Health's Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) provides $549,555.45 to The Trustees of the University of Pennsylvania to investigate the exposure and respiratory health effects of chemical constituents from electronic cigarette (e-cigarette) use among young adults. The project aims to: 1) evaluate the relationship between e-cigarette use and exposure to metals and aldehydes, 2) assess...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $265,239 to the University of North Carolina at Chapel Hill to conduct research on the effects of vaping-induced oxidation on nicotine analogs, such as 6-methyl nicotine, used in e-cigarettes. The key objectives are to: 1) analyze the chemical composition and metabolism of 6-methyl nicotine and nicotinamide vaping devices before and after...
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This $310,319 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program will support the University of Louisville in conducting formative research to develop a motivation-based adolescent vaping typology to inform the development of tailored cognitive behavioral e-cigarette cessation interventions.

The key objectives are to: 1) identify different types of adolescent e-cigarette users based on their motivations for use, 2) determine cognitive and behavioral intervention targets specific to each user type, and 3) gather adolescent input to ensure the acceptability of the cessation interventions. This mixed methods study will recruit 1,200 high school students who have used e-cigarettes in the past month to collect self-report data and conduct focus groups. The findings will fill critical knowledge gaps and enable the creation of developmentally appropriate, theory-driven e-cigarette cessation treatments tailored to adolescent user types, which will be evaluated in future clinical trials.

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