Project Grant R33AA031088
- Federal Grant Award Summary The University of Pennsylvania received a $569,223 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective August 1, 2025, through July 31, 2030. This research project examines the efficacy and tolerability of ketone supplement (KS) drinks in reducing alcohol craving and consumption among individuals with Alcohol Use Disorder (AUD). The research investigates two primary...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of Pennsylvania a Project Grant of $115,307 under the Alcohol Research Programs (CFDA 93.273) for the period September 1, 2025, through August 31, 2027. This K99/R00 career development award supports research examining the neuropharmacological effects of the ketogenic diet (KD) on alcohol intoxication in both healthy individuals and those with alcohol use disorder (AUD). The research...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of Pennsylvania $727,664 under the Alcohol Research Programs (CFDA 93.273) to conduct multi-omics spatial analysis examining the genomic consequences of ethanol exposure in mouse brain cells. The research, awarded May 1, 2026 with completion targeted for February 28, 2031, involves simultaneous quantification of open chromatin landscapes and cytoplasmic transcriptomes in...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of Pittsburgh a $459,343 Project Grant on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate the mechanisms through which alcohol affects prefrontal cortex (PFC) circuits. The research focuses on vasoactive intestinal peptide-expressing interneurons (VIP-INs) and their role in moderating drinking behavior and regulating affective changes...
- Federal Project Grant Award Summary Award Details: Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, received a $585,203 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) on September 20, 2025. The award extends through July 31, 2030, and is being conducted in Pennsylvania. Research Products and Services: The grant funds a comprehensive preclinical research investigation...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of North Carolina at Chapel Hill a Project Grant totaling $653,214 under the Alcohol Research Programs (CFDA 93.273) with an award date of May 1, 2026, and completion date of January 31, 2031. This research project investigates the mechanisms by which adolescent binge drinking induces reversible epigenetic suppression of cholinergic neuron function and resulting cognitive deficits in...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $188,313 to the University of Tennessee Health Science Center on September 26, 2025, under the Alcohol Research Programs (CFDA 93.273) to support research evaluating the synergistic effects of developmental and adult alcohol exposure on Alzheimer's disease-related phenotypes through September 2027. The research investigates whether ethanol exposure during critical periods of hippocampal...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded The Ohio State University a Project Grant totaling $474,223 on May 11, 2026, through the Alcohol Research Programs (CFDA 93.273) to support research on the mechanisms and neuroprotective targets in alcohol-induced brain injury. The research project, which extends through January 31, 2031, will investigate the brain region- and cell-specific mechanisms underlying alcohol-induced developmental...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $560,108 to the University of Florida, Division of Sponsored Research on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273). The project, titled "Attentional Ability and Resilience to Alcohol Use Disorder: Neurocognitive Mechanisms," will operate through August 31, 2030. This research project delivers neurocognitive and neuroimaging investigation services...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $733,704 to Lovelace Biomedical Research Institute on September 1, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a multimodal neuroimaging study examining the neural mechanisms underlying spatial memory deficits in children and adolescents with prenatal alcohol exposure (PAE). The award, with a completion date of June 30, 2030, supports comprehensive research...
The University of Pennsylvania received a $796,391 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to conduct a three-year research initiative spanning June 1, 2026 through May 31, 2029. This R33-phase project will investigate the mechanistic effects of exogenous ketone supplementation (25 grams) on brain nicotinamide adenine dinucleotide (NAD+) concentrations and neurocognitive function during acute alcohol exposure in healthy adult drinkers. Building on preliminary R21 findings, the research will employ advanced 7 Tesla magnetic resonance imaging and spectroscopy to quantify cerebral NAD+ levels and assess functional brain responses to alcohol using stop signal task testing. The project will enroll 40 healthy men and women ages 21-50 in a randomized, counterbalanced crossover study comparing ketone supplementation versus placebo conditions. Primary deliverables include collection and analysis of multimodal neuroimaging data, functional magnetic resonance imaging assessments of inhibitory control, blood biomarker quantification, and mechanistic characterization of how ketone-induced NAD+ metabolism modulation alters neurobiological and behavioral responses to alcohol. These research outputs are designed to advance fundamental understanding of alcohol sensitivity and tolerance modulation, with potential applications for developing improved alcohol-related treatment and prevention strategies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $796.4k | 5/28/26 |