Project Grant R21AA031766
- This $455,605 Project Grant was awarded on May 1, 2025 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award will fund research at the University of Iowa to examine the impact of chronic alcohol consumption on metabolic function and tau pathology in Alzheimer's disease (AD). Key objectives include: Assessing the influence of chronic ethanol exposure on metabolic function and tau pathology in the...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded Northeast Ohio Medical University (Neomed) a $439,865 Project Grant to investigate the impact of alcohol on brain acetylation changes and tau-based dementia in an Alzheimer's disease mouse model. The research aims to understand how alcohol disrupts brain glucose metabolism, histone acetylation, and tau protein degradation, potentially accelerating the progression of tauopathy and...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $136,236 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Washington for the project "Uncovering the Synergistic Effects of Chronic Alcohol Use and Pathological Tau Expression". The project aims to investigate the progression of behavioral impairment, the time course of aging-related biomarkers, and the development of neurodegeneration resulting from alcohol intake and tau...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $468,534 to the University of Southern California to examine alcohol consumption as a modifiable risk factor for Alzheimer's disease and related dementias (ADRD). The study aims to delineate the relationship between midlife alcohol consumption and late-life ADRD diagnosis and onset, with a focus on potential sex differences. It will also test the interaction between alcohol consumption...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Federal Alcohol Research Programs (CFDA 93.273), awarded a $156,444 Project Grant to Vanderbilt University. The grant, which runs from January 25, 2026 to July 31, 2028, aims to elucidate the neural mechanisms underlying cue-alcohol associations and how they are changed by chronic alcohol exposure and abstinence. The project will utilize in vivo techniques to investigate the role of D2-receptor-containing medium spiny...
- This Project Grant award of $550,417.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to determine how heavy alcohol exposure interacts with aging to dysregulate neuroimmune function and microglia activity, leading to neurodegeneration and cognitive deficits. The key objectives are to investigate how alcohol intake in the aged brain impacts microglial phagocytic and inflammatory processes, and how this...
- This federal Project Grant award of $498,000.00, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research at the University of North Carolina at Wilmington (UNCW) to investigate how adolescent binge drinking impacts the development and integration of new hippocampal neurons in adulthood. The research will use a transgenic mouse model to track the fate of neural progenitor cells and test whether...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $597,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Pennsylvania State University on June 1, 2025. The project, titled "Sex-Dependent Shifts in Behavioral Profiles and Cortical Signaling Following Adolescent Binge Drinking", aims to characterize changes in behavior, cortical adaptations in somatostatin neuron function and peptide signaling, and functional connectivity following...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
- The University of Pittsburgh has been awarded a $147,486 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) to conduct research on the effects of chronic alcohol consumption on prefrontal cortex inhibitory interneurons. The project aims to investigate how metabotropic glutamate receptor 5 (mGlu5) regulates synaptic transmission and plasticity onto these interneurons, and how chronic alcohol exposure may alter these mechanisms. The...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $188,313 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Tennessee Health Science Center to evaluate the synergistic effects of developmental and adult alcohol exposure on Alzheimer's-related phenotypes. The project aims to investigate whether alcohol exposure during critical brain development periods and later in adulthood could increase the risk of developing Alzheimer's disease or other dementias. The 2-year project will use mouse models to test hypotheses around the impacts of this dual alcohol exposure on the hippocampus and entorhinal cortex, regions highly susceptible to alcohol-induced alterations. The results could provide important insights into the potential role of alcohol as an environmental risk factor for Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $188.3k | 9/26/25 |