Project Grant R25GM166887
- The National Institute of General Medical Sciences awarded Vanderbilt University $1.741 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop genetically encoded dual-visible protein tags for molecular-resolution cell imaging. The project addresses the resolution gap between light microscopy and cryo-electron tomography (cryo-ET) by engineering universal protein tags simultaneously visible under both light microscopy and electron...
- The National Institutes of Health Office of the Director awarded Vanderbilt University $1,281,400 on May 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire a LUMICKS C-TRAP DYMO300 microscope system. The instrument combines optical tweezers for exerting forces on molecules and cells with confocal imaging and single-molecule fluorescence detection capabilities, supported by a microfluidic laminar flow platform for assay construction and protocol refinement. The...
- The National Institute of General Medical Sciences awarded $435,875 to Vanderbilt University on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate structural mechanisms of calcium signaling at endoplasmic reticulum–mitochondria contact sites (EMCS). The research employs advanced structural techniques including X-ray crystallography and cryo-electron microscopy to elucidate how inositol 1,4,5-trisphosphate receptors (IP3Rs) mediate calcium...
- The National Institute of General Medical Sciences awarded Vanderbilt University $277,370 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular sensing and signal integration. The research program comprises three interconnected projects examining how cells perceive and integrate distinct types of biological information. Project 1 investigates crosstalk and synergy between canonical signaling pathways, identifying the...
- The National Institute of General Medical Sciences awarded Vanderbilt University Medical Center $433,985 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical methods for microbiome data analytics. The research addresses critical gaps in microbiome epidemiology and bioinformatics over a five-year period through December 31, 2030. The project focuses on two primary objectives: first, benchmarking unmeasured confounding effects in...
- Federal Grant Award Summary Vanderbilt University received a $1.2M project grant awarded September 1, 2025, from the National Science Foundation's Division of Computer and Network Systems under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The project, titled "Intelligent Cyber Microscopy System for Long-Term Microscope Imaging" (ICMS), will develop an AI-powered cyber-physical system that transforms biological microscopy capabilities through the...
- The National Institute of General Medical Sciences awarded Vanderbilt University $435,875 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on epigenetic control of tissue regeneration across species and life stages. The award funds investigation into how gene activity is regulated to enable tissue regeneration in organisms such as planarians, teleost fish, and salamanders that retain regenerative capacity throughout their lives,...
- The National Institute of General Medical Sciences awarded Vanderbilt University $474,174 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate allosteric mechanisms regulating aminolevulinic acid synthase (ALAS) enzyme structure, activity, and protein interactions in eukaryotic heme synthesis. The research combines structural biology, enzymology, protein engineering, in silico modeling, and cell-based studies to determine how ligand and...
- The National Science Foundation (NSF) Integrative Activities program (CFDA #47.083) awarded Vanderbilt University $965,000 to acquire a state-of-the-art 50-kV electron beam lithography (EBL) tool. This major research instrumentation will be housed in Vanderbilt's shared-use cleanroom facility, which serves multiple universities in the Southeast, including Historically Black Colleges and Universities (HBCUs) such as Fisk University and Tennessee State University. The EBL tool will enable...
- The National Science Foundation Division of Biological Infrastructure awarded Vanderbilt University $431,236 on August 15, 2026, under the Biological Sciences program (CFDA 47.074) to develop computational tools for integrating spatial transcriptomics data across multiple tissue sections and reconstructing three-dimensional tissue architecture. The project will create a unified computational framework combining graph representation learning, local alignment, contrastive learning, and...
The National Institute of General Medical Sciences awarded Vanderbilt University $512,849 on August 11, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to deliver the E.M.P.O.W.E.R. (Electron Microscopy Program for Organellar Workflow Education and Research) training initiative. Vanderbilt will train twenty trainees annually in hands-on electron microscopy techniques spanning transmission electron microscopy, correlative light and electron microscopy, and 3D electron microscopy using focused ion beam-SEM and serial block face-SEM. Participants will gain practical expertise in fixation chemistry, resin embedding, ultramicrotomy, sectioning, image acquisition, and 3D data reconstruction using advanced computational platforms. The curriculum integrates classical electron microscopy craftsmanship with modern correlative and computational imaging, and includes structured instruction in complementary advanced light microscopy approaches including confocal laser scanning microscopy, Airyscan, structured illumination microscopy, total internal reflection fluorescence, and light sheet microscopy to enable trainees to bridge molecular and ultrastructural scales of analysis. The award supports work performed in Nashville, Tennessee, with performance extending through March 31, 2031. This R25 project grant directly addresses the nationwide shortage of skilled electron microscopy practitioners by training the next generation of biomedical researchers to apply, innovate, and sustain cutting-edge electron microscopy technologies in scientific discovery.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/12/26 | ||
| Not listed | $0 | 8/11/26 | ||
| Not listed | $512.8k | 8/10/26 |