Project Grant R35GM161399
- Federal Grant Award Summary Wake Forest University Health Sciences received a $387,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This award supports fundamental biomedical research investigating calcium sensing mechanisms and mitochondrial homeostasis—specifically examining how calcium-binding proteins regulate mitochondrial function...
- Federal Project Grant Award Summary Vanderbilt University received a $342,570 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2026, with completion targeted for February 28, 2030. The award supports fundamental research examining ubiquitin-mediated regulation of DNA repair pathway selection at persistent double-strand breaks in budding yeast (Saccharomyces cerevisiae). The...
- Federal Grant Award Summary Vanderbilt University has been awarded $558,651 through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) for a five-year Project Grant beginning August 1, 2025 and concluding July 31, 2030. The award supports research on the discovery and engineering of ribosomally synthesized and post-translationally modified peptides (RIPPs), with focus on advancing genomics, enzymology, and structure-function...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $186,224 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through February 28, 2031. The grant supports a five-year research project investigating immunometabolic regulation of CD8 T cell dynamics in human critical illness and sepsis. The research addresses the mechanisms linking metabolic...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $456,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through January 31, 2031. This award supports fundamental research to elucidate the structure and transport mechanisms of the mitochondrial pyruvate carrier (MPC), a protein complex essential for transporting...
- Federal Project Grant Award Summary The Leland Stanford Junior University received a $423,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 6, 2026, with completion targeted for February 28, 2031. This award funds fundamental research to elucidate the molecular mechanisms governing membrane protein complex assembly at the human endoplasmic reticulum (ER) membrane....
- Federal Grant Award Summary Vanderbilt University received a $631,259 Project Grant awarded on August 20, 2025, by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project, which extends through June 30, 2029, focuses on elucidating the mechanisms by which calcium extrusion proteins—specifically the plasma membrane calcium-transporting ATPase 1 (PMCA1) and...
- Federal Grant Award Summary The University of Virginia received a $353,430 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 15, 2025, through July 31, 2029. This research project focuses on investigating the regulation of ceramide-1-phosphate (C1P) metabolism in cellular signaling networks, specifically examining how C1P facilitates metabolic reprogramming in response...
- Federal Grant Award Summary Yale University received a $2.31 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 8, 2025, with completion targeted for September 7, 2029. The research project, titled "Decoding the Molecular Choreography of Diverse Vesicle Release Mechanisms," will advance fundamental understanding of large dense-core vesicle (LDCV) fusion...
- Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with a completion date of June 30, 2030. This research project, titled "Unraveling the Mechanisms of Protein Sorting and Localization to Organelles," aims to elucidate the molecular mechanisms governing protein biogenesis on mitochondrial and...
Federal Grant Award Summary Vanderbilt University received a $435,875 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026 through January 31, 2031. This award funds fundamental research to elucidate the structural mechanisms of calcium signaling at endoplasmic reticulum-mitochondria contact sites (EMCs), with particular focus on inositol 1,4,5-trisphosphate receptors (IP3Rs) and ER-mitochondria tethering complexes. The research employs advanced structural biology techniques including X-ray crystallography and cryo-electron microscopy (cryo-EM), combined with biochemical and functional assays, to understand how these molecular interactions regulate calcium transfer necessary for ATP production and mitochondrial function. The primary deliverables include characterization of IP3R-mediated calcium release mechanisms, structural analysis of tethering complex dynamics between PTPIP51 and VAPB proteins, and development of an in vitro reconstitution system to model the membrane interface of EMCs. This research aims to identify potential therapeutic targets for diseases linked to mitochondrial dysfunction, including metabolic disorders, neurodegenerative diseases, and cancer. The work will provide critical insights into how specific mutations and posttranslational modifications influence EMC assembly and disassembly, with direct implications for understanding cell survival pathways and disease progression mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 5/26/26 |