This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $607,682 to the Oklahoma Medical Research Foundation (OMRF) to develop scalable methods for rapid phenotyping and functional testing of genetic variants using zebrafish models. The key objectives are to: 1) establish a high-throughput phenotyping pipeline using a knockout library of 80 mutant zebrafish lines, and 2) optimize and expand the targeting...
This federal Project Grant award, valued at $1,023,185 and provided by the National Institutes of Health under the Research Infrastructure Programs (CFDA 93.351), supports the development of conditional gene animal resources and precision genome editing tools for the zebrafish model organism. The primary awardee, Iowa State University, will expand the community resource for Cre recombinase-based conditional gene studies in zebrafish, covering embryonic development, major tissues, and...
This Project Grant award, valued at $194,375 and funded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to develop robust genome editing tools for generating floxed alleles and editing amino acid changes in the zebrafish model system. The key objectives are to: 1) Establish a synthetic exon-mediated integration approach to reliably create floxed alleles in zebrafish, enabling conditional gene knockout studies; and 2) Expand the...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) provides $769,325 to the University of Utah to support a project titled "Multimodal Phenotyping of Zebrafish Models of Human Disease." The project aims to generate and characterize animal models for hundreds of human disease genes using advanced technologies like CRISPR, single-cell RNA sequencing, and automated physiological and...
The federal Project Grant award R24OD036061, totaling $743,926.00, was provided by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351). The grant will develop a resource of rigorously validated, translatable zebrafish models of previously undiagnosed human genetic diseases. The project will generate humanized zebrafish genetic models of selected gene variants identified through collaboration with clinical diagnostic centers,...
The National Institutes of Health (NIH) awarded Iowa State University of Science and Technology a $181,754 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to develop efficient methods for introducing single nucleotide polymorphisms (SNPs) and variants of uncertain significance (VUS) into the zebrafish genome. The goal is to create a gene editing technique called "GenEWALD" that can reliably and cost-effectively generate zebrafish models with targeted genomic...
This $340,302 Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will support the Medical University of South Carolina (MUSC) in modernizing its animal research microenvironment monitoring and increasing housing capacity through the deployment of cutting-edge technologies. The key products and services to be delivered include upgrading the animal housing caging system and integrating remote monitoring capabilities to...
This $16,000,000 Project Grant award from the National Institutes of Health (NIH) Office of the Director (CFDA 93.352 - Construction Support) will fund the construction of a new vivarium facility within the Heritage Translational Research Center at Ohio University. The vivarium will expand the university's biomedical research capacity by increasing the total mouse cage capacity by 64% and improving efficiency, biosecurity, and equipment for animal-based studies conducted by researchers in the...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $350,000 to the University of Illinois Chicago (UIC) to enhance the environmental monitoring capabilities of its animal research facilities. Specifically, the award will fund the purchase and installation of a REES Scientific environmental monitoring system across 8 centrally managed animal facilities at UIC, totaling approximately 135,000 sq. ft. of animal...
This Project Grant award of $185,500 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) will enable Idaho State University (ISU) to detect, monitor, and track extrinsic factors such as temperature, humidity, light, noise, and vibration within the animal research facility. The goal is to improve research outcomes, animal welfare, and facility operations by maintaining consistent and ideal environmental conditions for research animals, reducing...