This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) supports the development of innovative in vivo animal models for studying mitochondrial DNA (mtDNA) diseases. The $629,508 award to the University of Texas at Austin, effective September 16, 2024 through August 31, 2028, aims to generate designer zebrafish models with specific mtDNA variants to enable new research approaches for diagnosing and treating these complex diseases. The project will leverage advanced gene editing tools to introduce mtDNA variants in protein-coding and tRNA genes, expanding the range of alleles that can be modeled. Additionally, the project will develop new tissue-specific mtDNA animal models and engage the research community to enhance access to these novel resources. The outcomes will include a series of validated zebrafish lines harboring designer mtDNA variants to facilitate hypothesis testing and discovery science around mitochondrial diseases, which have a minimum prevalence of 1 in 5,000 adults with limited treatment options.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $629.5k | 9/17/24 |