This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $629,508 to the University of Texas at Austin to generate animal models of mitochondrial DNA (mtDNA) disease. The project aims to develop designer zebrafish models harboring specific mtDNA variants to enable new approaches for diagnosing and treating mitochondrial disorders, which have a minimum prevalence of 1 in 5,000 adults and few effective...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of the first murine animal model and adeno-associated virus (AAV)-based gene therapy for mitochondrial ATP6 (mtatp6) diseases. The $498,000 award, valid from August 1, 2024 to June 30, 2027, aims to create a novel mitochondria-targeting base editing technology to generate a truncated...
This federal Project Grant award with ID R21OD037651, provided by the Office of the Director at the U.S. Department of Health and Human Services, supports the development and validation of a novel mouse model to study the role of mitochondrial dysfunction in a range of human diseases.
The $236,250 award, with a performance period from July 1, 2024 to June 30, 2026, will enable researchers at the University of Rhode Island to generate and characterize an inducible mitochondrial DNA mutator...
This federal Project Grant award, provided by the National Institutes of Health under the Research Infrastructure Programs (CFDA 93.351), will develop a resource of rigorously validated, translatable zebrafish models of previously undiagnosed human genetic diseases. The University of Oregon will collaborate with clinical sites and research consortia to obtain genetic information about new cases of undiagnosed rare human diseases. They will then generate humanized zebrafish genetic models of...
This Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $999,996.00 in funding to the University of South Alabama to conduct research aimed at developing fundamental knowledge required for generating artificial mitochondria. The key objectives of the 4-year project are to:
Identify new proteins that contribute to the species-specificity of mitochondrial DNA (mtDNA) replication,
Reconstitute replication of human mtDNA in mouse cells by...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $777,500 to the University of Washington to conduct research aimed at understanding the cellular mechanisms that regulate mitochondrial DNA (mtDNA) heteroplasmy and its intersection with mitochondrial quality control pathways. The key objectives are to: 1) investigate how mitochondrial quality control mechanisms regulate mtDNA...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to understand the role of mitochondrial and nuclear genomic variation in mitochondrial dysfunction and associated diseases. The $399,766 award to the University of Kansas Center for Research Inc., spanning January 1, 2025 to December 31, 2026, will leverage threespine stickleback fish populations with exceptional mitogenomic divergence to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to determine the biochemical and molecular mechanisms of RNASE Z-mediated deampylation in mitochondria. The $349,915 award to the University of Texas Southwestern Medical Center aims to investigate the functional importance of protein ampylation, a novel post-translational modification, and the enzymes that reverse this...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $744,781 to the University of Texas at Austin to conduct collaborative research on the genetic and energetic basis of mitonuclear incompatibilities during speciation in swordtail fish. The key objectives are to: 1) Identify specific combinations of mitochondrial and nuclear genes that contribute to reproductive barriers and hybrid incompatibilities using genomic tools, 2)...
This NIH R24 project grant, titled "Multimodal Phenotyping of Zebrafish Models of Human Disease," was awarded by the National Institutes of Health (NIH) Office of the Director under the CFDA 93.351 Research Infrastructure Programs. The $769,325 award to the University of Utah's Office of Sponsored Projects Division will support the development of a comprehensive platform to generate and characterize hundreds of zebrafish disease models. The project will leverage recent technological...