The University of California, San Diego will receive $2,844,000 under a three-year Project Grant from the Department of Health and Human Services' National Institute of General Medical Sciences to develop tools and models to decode mitochondrial morphology dynamics and predict cell fate decisions. The grant funds research from September 2022 to August 2025 under the Biomedical Research and Research Training program (CFDA 93.859).
Specifically, the University will expand its prototype computational image processing pipeline to automatically track mitochondrial networks in multiple cell types. It will elucidate the coupling between mitochondrial morphology and cellular fate in intestinal epithelial organoids differentiating intestinal stem cells into Paneth cells. Finally, the University will create a predictive model linking mitochondrial network morphology to underlying signaling drivers and the fate decisions caused by different morphologies. This research aims to open a new window into mitochondrial biology with potential applications to mitochondria-related diseases including cancer, epilepsy, Parkinson's, and Alzheimer's.
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