The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a 5-year, $200,016 Project Grant to the Regents of the University of California, San Francisco (UCSF) to develop a non-viral platform technology for genome editing of hematopoietic stem cells to treat Artemis-deficient Severe Combined Immunodeficiency (ART-SCID). The key objectives are to 1) develop non-viral techniques of targeted integration to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $192,788 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, San Diego (UC San Diego) to identify regulators of plasmacytoid dendritic cell (pDC) function and exhaustion. The research aims to provide the first genome-wide analysis of type I interferon (IFN-I) regulation in pDCs, which are critical for the body's defense against viral infections and cancers. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $385,575 to the University of California, San Diego (UCSD) to investigate the crosstalk between immune dysregulation and impaired wound healing in an inherited autoinflammatory disease called disabling pansclerotic morphea (DPM). The key objectives of this 5-year research project are to: 1) determine the mechanism by...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $492,000.00 to The Regents of the University of California, San Francisco (UCSF) to conduct systematic genetic research on the mechanisms governing immunogenic cell death (ICD). The research aims to decipher the signaling pathways and molecular processes that regulate the immune system's ability to recognize...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $256,504 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF). The grant will fund the planning of an open-label, randomized, controlled Phase 2C clinical trial to evaluate novel 4-month treatment regimens for isoniazid-monoresistant tuberculosis (IMR-TB) compared to the current 6-month standard of care. The trial...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $785,511 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Chicago. The purpose of this 5-year project, which commenced on January 24, 2025, is to leverage induced pluripotent stem cell-derived macrophages to: Characterize inter-individual and inter-population variability in immune responses to Mycobacterium tuberculosis and influenza virus infections in humans....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,767,750 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Swiss Institute of Bioinformatics (Sib) to develop the Pathogen Data Network (PDN). The PDN will create a global framework to integrate and share diverse pathogen-related data types, including genomics, transcriptomics, proteins, and epidemiological information. Key components include establishing a network of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $287,000 to The Regents of the University of California, San Francisco (UCSF) to determine whether genetic mutations that alter IL-17 signaling contribute to the etiology of autoimmune diabetes. The research aims to understand the mechanism by which altered IL-17 signaling leads to autoimmune diabetes, using...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $794,045 to the Regents of the University of California, San Francisco (UCSF) to study host mechanisms that drive HIV reservoir decay and sustained viral control. The goal is to identify potential therapeutic candidates for HIV cure strategies. The award funds research to characterize the role of class II...
The Washington University received a $2,483,910 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award aims to conduct research into "Genetic Errors of Immunity" (GEI), which encompasses novel molecular mechanisms behind Primary Immune Regulation Disorders (PIRD), a subset of Inborn Errors of Immunity. The research project consists of three integrated components: 1)...