Project Grant R21TR006460
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Indiana University Indianapolis $692,850 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop new Down syndrome mouse models that clarify sex-specific co-occurring phenotypes associated with Trisomy 21. The project creates the first systematic determination of the sources of sex differences in Down syndrome phenotypes using offspring from DP16 × Four Core...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $691,306 to Trustees of Indiana University (Indiana University Indianapolis) on August 15, 2026, under the Aging Research program (CFDA 93.866). The award funds research integrating real-world evidence from electronic medical records, cell line assays, and single-cell omics via deep reinforcement learning to identify repurposable drugs for Alzheimer's disease treatment. The project applies deep transfer...
- The National Institutes of Health Office of the Director awarded University of California Irvine $6.132 million on August 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the neurobiological basis for cognitive dysfunction and dementia in aging adults with Down syndrome. The project uses spatial multi-omics techniques—combining transcriptomics, epigenomics, and proteomics—to analyze over 100 clinically characterized brain samples from individuals with Down...
- Federal Grant Award Summary The National Institutes of Health (NIH) Office of the Director awarded Indiana University Indianapolis $1,303,054 under the Trans-NIH Research Support program (CFDA 93.310) to conduct a two-year Project Grant (August 1, 2025–July 31, 2027) examining genetic modifiers of Down syndrome phenotypes. The project creates novel mouse models with genetically diverse backgrounds to better represent the human condition of Trisomy 21 (TS21), identifying modifier genes and...
- The National Institute on Aging awarded Indiana University Indianapolis $109,795 on August 20, 2026, under the Aging Research program (CFDA 93.866) to evaluate amyloid dynamics and cerebral amyloid angiopathy burden. The project examines amyloid plaque redistribution and cerebral amyloid angiopathy development through genetic and pharmacological methods, and tests whether dietary and exercise interventions mitigate cerebral amyloid angiopathy burden. The research evaluates glial-based mechanisms...
- The National Institute on Aging awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $791,039 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods enabling patient-centered prognostic profiling for Alzheimer's disease and related dementias that accounts for individual cognitive resilience in response to neuropathological changes. The work will model each patient's distinct connectome architecture and cognitive...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- The National Institutes of Health Office of the Director awarded $2.693 million to the University of Wisconsin–Madison on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to establish an Alzheimer's disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes. The research addresses the underrepresentation of individuals with Down syndrome in Alzheimer's disease therapeutic trials by characterizing biomarker progression in this...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- The National Institute of Neurological Disorders and Stroke awarded $225,144 to Trustees of Indiana University (Indiana University Indianapolis) on December 5, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of neutrophil contributions to comorbid Alzheimer's disease and vascular contributions to cognitive impairment and dementia. The research examines mechanisms by which neutrophils worsen...
The National Institutes of Health Office of the Director awarded Indiana University Indianapolis $435,875 on August 3, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop molecular glue degraders targeting the amyloid precursor protein (APP) for prevention and treatment of Down syndrome-associated dementia. The project addresses the unmet clinical need for effective therapeutic strategies targeting APP overexpression, which drives amyloid-beta production and neurodegeneration in individuals with Down syndrome. The recipient institution has discovered targeted protein degradation compounds that selectively promote lysosomal degradation of APP by stabilizing the interaction between APP and CAPRIN1 (cytoplasmic activation/proliferation-associated protein 1). The lead compound crosses the blood-brain barrier, is orally bioavailable, and significantly reduces APP levels and amyloid-beta plaque burden in preclinical models. The research applies AI-assisted ligand- and structure-based drug design to optimize a focused library of lead derivatives. Work is performed in Indianapolis, Indiana, with a period of performance extending from August 3, 2026, to July 31, 2028. The assistance type is a project grant, classified under the Trans-NIH Research Support program, which funds research support activities across multiple NIH Office of the Director offices and is reviewed for scientific and technical merit by a scientific review group and for program relevance by a national advisory council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 8/3/26 |