Project Grant K99AG097892
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $691,306 to Trustees of Indiana University (Indiana University Indianapolis) on August 15, 2026, under the Aging Research program (CFDA 93.866). The award funds research integrating real-world evidence from electronic medical records, cell line assays, and single-cell omics via deep reinforcement learning to identify repurposable drugs for Alzheimer's disease treatment. The project applies deep transfer...
- The National Institute on Aging awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $791,039 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods enabling patient-centered prognostic profiling for Alzheimer's disease and related dementias that accounts for individual cognitive resilience in response to neuropathological changes. The work will model each patient's distinct connectome architecture and cognitive...
- The National Institute on Aging awarded the Trustees of Indiana University $1.232 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop AI-driven virtual screening pipelines and computational tools for identifying blood-brain-barrier-penetrant drug candidates against Alzheimer's disease and related dementias. The funded research encompasses three interconnected aims: developing AI-driven virtual screening pipelines incorporating small-molecule foundation...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Trustees of Indiana University (Indiana University Indianapolis) on April 15, 2026, under the Aging Research program (CFDA 93.866) for development and validation of a humanized SERPINA3 mouse model to advance Alzheimer's disease research. The award funds creation of a transgenic mouse model that expresses human SERPINA3 in an Alzheimer's disease context, enabling in vivo testing of...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging awarded Purdue University $387,183 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop mass spectrometry-based proteomics strategies examining post-translational modifications related to protein aggregation and extracellular vesicle-mediated propagation in neurodegenerative disease, with emphasis on Alzheimer's disease. The recipient will establish a novel proteomics platform to profile N-terminal acetylation landscapes in primary...
- The National Institute on Aging awarded $431,996 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and deliver INSPIRE (Investigating Neurosciences, A Summer Program to Ignite Research and Education), an immersive summer research education program designed to attract and retain undergraduate science majors pursuing careers in Alzheimer's disease and related dementias research....
- The National Institute on Aging, within the National Institutes of Health and the Department of Health and Human Services, awarded the University of California Irvine $739,365 on September 15, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG098878) to develop and evaluate structure-guided active and passive beta-amyloid immunotherapies targeting early, non-fibrillar assemblies in Alzheimer's disease. The project develops vaccines and monoclonal antibodies directed against...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Emory University $657,222 in Project Grant R01AG093923 on February 15, 2026, under the Aging Research program (CFDA 93.866). The award funds research into the amyloid scaffold hypothesis in Alzheimer's disease. The project investigates how proteins co-accumulate with amyloid-beta in diseased brains, testing whether this protein scaffolding—rather than direct amyloid toxicity—drives pathophysiology in...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging awarded Indiana University Indianapolis $109,795 on August 20, 2026, under the Aging Research program (CFDA 93.866) to evaluate amyloid dynamics and cerebral amyloid angiopathy burden. The project examines amyloid plaque redistribution and cerebral amyloid angiopathy development through genetic and pharmacological methods, and tests whether dietary and exercise interventions mitigate cerebral amyloid angiopathy burden. The research evaluates glial-based mechanisms influencing cerebral amyloid angiopathy development, specifically assessing astrocyte-microglia crosstalk effects on plaque redistribution. Three aims structure the work: Aim 1 evaluates amyloid plaque distribution using the APOEE4 genotype in 5XE4 and 5XE3 mouse models across multiple timepoints; Aim 2 assesses amyloid plaque changes following anti-amyloid beta immunotherapy in 5XFAD mice (low-expressing line 7031); and Aim 3 tests lifestyle-based intervention strategies to mitigate cerebral amyloid angiopathy development. Performance occurs in Indianapolis, Indiana, with a period of performance from August 20, 2026, through July 31, 2028. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $109.8k | 8/19/26 |