This $382,090 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research by the University of Wisconsin - Madison to investigate the role of human-specific haplotype diversity on cell fate commitment. The primary objectives are to:
- Elucidate the functional implications of haplotype diversity at the cellular level across different cell types, and
- Identify critical factors contributing to ethnicity-based disease risk and cell-type-specific vulnerabilities.
The researchers will leverage human induced pluripotent stem cells (iPSCs) from diverse ancestral backgrounds, genome editing techniques, and a range of cellular assays to study how variations in non-coding genomic regions impact cell fate determination and cell state maintenance. The research aims to shed light on the functional significance of haplotype diversity and enhance the ability to predict complex disease risk across different populations. This 5-year project is scheduled to run from September 1, 2024 through August 31, 2029.
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