Project Grant R01DK143671

Award Date 9/15/24
Completion Date 7/31/29
Dollars Obligated $1.6M
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90089, USA
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This is a Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant, totaling $1,630,964.00, was awarded to the University of Southern California (USC) on September 15, 2024 with a completion date of July 31, 2029.

The project aims to study the dynamic spatial configuration of hematopoietic stem and progenitor cells (HSPCs) during blood and immune cell regeneration in the bone marrow. The researchers will use advanced technologies like MEMOIR and seqFISH to (1) map the spatial organization of HSPCs, (2) investigate changes in their spatial positioning during hematopoiesis and upon demand for specific blood cell types, and (3) determine the impact of the HSPCs' spatial context on their intercellular signaling and fate decisions.

The project includes a sub-award to the California Institute of Technology (Caltech) to collaborate on aspects of this research. The findings are expected to provide novel spatial insights into blood and immune cell regeneration, with potential impacts on various biomedical fields including immunology, hematology, tissue engineering, aging, and cancer.

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